Adjunctive and Combination Therapy Blaise F.D. Bourgeois Frank Gilliam Introduction A historical review of the practices of predominant combination therapy versus predominant monotherapy in the medical treatment of epilepsy reveals…
Rapid Substitution of Antiepileptic Drugs Blaise F. D. Bourgeois Introduction In general, substituting one antiepileptic drug for an other is a relatively slow process that is carried out over several…
Routine Monitoring for Safety and Tolerability During Chronic Treatment with Antiepileptic Drugs John M. Pellock L. James Willmore Michael D. Privitera Introduction The goal of epilepsy therapy is to control…
Starting and Stopping Treatment Olivier Dulac Ilo E. Leppik David W. Chadwick Luigi Specchio Introduction Although single seizures are common events—as many as 9% of the population have at least…
Choice of Antiepileptic Drugs Elinor Ben-Menachem Jacqueline A. French Introduction When the diagnosis of epilepsy has been made and extraneous factors that can provoke seizures are eliminated, then there is…
Compliance Joyce A. Cramer Introduction Issues of compliance with drug regimens are universal across all medical disciplines. The impact of taking none or less than the appropriate amount of an…
Mechanisms of Drug Resistance Sanjay M. Sisodiya Heinz Beck Wolfgang Löscher Annamaria Vezzani Introduction For most patients with a diagnosis of epilepsy requiring drug treatment, the outlook is favorable. In…
Drug Treatment in the Elderly Ilo E. Leppik Angela K. Birnbaum Introduction The elderly are the most rapidly growing segment of the population, and demographic trends predict that their number…
Gender Issues for Drug Treatment Anne Sabers Cynthia L. Harden Introduction Potential health risks associated with long-term drug treatment raise specific concerns and considerations for the treatment of epilepsy across…
Drug Treatment in Adolescents Eileen P. G. Vining Introduction In general, the incidence of epilepsy tends to decrease slightly in adolescence. It appears to range from 20 to 60 per…
