Introduction Acromegaly is a medical condition defined by elevated serum growth hormone (GH) levels almost always secondary to hypersecretion by cells of the anterior pituitary. Descriptions of individuals consistent with…

Introduction Tumors of the pituitary gland and sellar region represent approximately 10% to 15% of all brain tumors. Several types of tumors may involve the sellar region, reflecting its complex…

Introduction The sellar and parasellar region is a complex and relatively small intersection of endocrine, neural, vascular, meningeal, and skeletal structures. Various types of mass lesions, inflammatory processes, cysts, and…

Introduction Performing the transsphenoidal procedure requires the neurosurgeon to master a unique set of surgical techniques. While the ultimate goal rests with the hypophysis and neuraxis, the surgical approach mandates…

Introduction Intraoperative imaging has played a substantial role in the history of transsphenoidal surgery. Cushing’s discontinued his use of transnasal pituitary surgery mainly because of limited visibility during the operation….

Introduction Like many advances in medicine, the transsphenoidal procedure as we know it today is the result of a long, relentless process. Many bold and creative pioneer surgeons have contributed…

Introduction Modern transsphenoidal approaches began with the contributions of Jules Hardy, who built on the legacy of earlier transsphenoidal approaches from Cushing’s to Norman Dott to Gerard Guiot. Hardy introduced…

Introduction The approach to tumors of the pituitary gland has undergone a developmental evolution during the past century. While Sir Victor Horsley performed the first transcranial approach to the pituitary…

Introduction The main purpose of this chapter is to provide a practical review of the visual and oculomotor manifestations of pituitary tumors. The close anatomical relationship between the pituitary gland…