Fig. 12.1 Chemical structures of MIBG and norepinephrine Fig. 12.2 Mechanism of MIBG accumulation in sympathetic nerve terminal. MIBG is uptaken to sympathetic nerve terminals via uptake-1, is transported to…
Fig. 4.1 Scientists who have worked alongside Michel Goedert in Cambridge – (from left) Valerie Buee-Sherrer, Tony Crowther, Ross Jakes, Maria Spillantini, Michel Goedert, Mike Smith, Molly Craxton and Masato…
Fig. 9.1 In patients with Lewy body disease, Lewy bodies and Lewy neurites are observed in not only the central nervous system but also the peripheral autonomic nervous system. The…
Fig. 13.1 Extracellular soluble A-syn oligomers play an important role in both the development and progression of PD. (a) The cascade of A-syn aggregation. The A53T mutation promotes the formation…
Fig. 15.1 Reduced respiratory response to hypercapnia The indices of VRH of the DLB patients, AD patients, and controls were 0.156 ± 0.10, 0.431 ± 0.04, and 0.466 ± 0.09, respectively (Fig. 15.2). VRH in DLB patients…
Fig. 10.1 (a–d) MRI findings of characteristic AD and DLB cases. (a) Probable AD case. Medial temporal lobe atrophy (MTA) is prominently evident bilaterally. (b) Probable DLB case. MTA is…
Fig. 11.1 Nigrostriatal dopaminergic synapse and targets of PET and SPECT ligands. Tyrosine is converted to L-DOPA by tyrosine hydroxylase. L-DOPA is then converted to dopamine, which is gathered into…
Fig. 1.1 Typical brain stem-type Lewy body (upper) and cortical Lewy body (lower) and the distribution of Lewy bodies in our first case Fig. 1.2 Alpha-synuclein-immunostained Lewy bodies in the…
Diffuse Lewy body disease (DLBD) Kosaka et al. [1], Dickson et al. [2], Lennox et al. [3] Lewy body dementia (LBD) Gibb et al. [4] Lewy body variant of Alzheimer’s…
Fig. 6.1 Differentiation between DLB and AD DLB by using neuropsychological tests. (a) ADAS word recall score and WAIS-R blocks design score. (b) Total MMSE score and MMSE calculation/attention score…
