Neupsy Key

Fig. 1.1 Orientation of the muscle biopsy. (a) Larger specimens can sometimes be oriented with the naked eye, but in many cases, the use of a dissecting microscope can ensure…

Fig. 2.1 Properly clamped peripheral nerve is fixed in glutaldehyde for resin embedding and EM processing Once in pathology laboratory, the fresh specimen is snap frozen in isopentane cooled in…

Fig. 3.1 3-mm punch skin biopsy for diagnosing small fiber neuropathy. (a) After cleaning the biopsy site, a 3-mm punch is placed on the site perpendicular to the skin surface…

Fig. 5.1 Hematoxylin and eosin stain (HE) shows active myopathy with a large collection of lymphocytic infiltrates in perimysium and surrounding a perimysial blood vessel. Alkaline phosphatase stain (ALK) shows…

Fig. 31.1 SMA type 1 . (a) H&E and (b) ATPase at pH 9.4 are images from the rectus abdominis muscle biopsy performed at age of 3 months. (c) H&E of spinal…

Fig. 23.1 Quadriceps muscle biopsy from this patient. (a) H&E stain, arrows point to the macrophages in perimysium and endomysia connective tissue with granular basophilic cytoplasm. (b) Nonspecific esterase stain,…

Fig. 29.1 Representative images from a separate 10-year-old boy with RYR1 mutation. (a) H&E stain shows marked fiber size variation. (b) NADH-TR stain shows well demarcated central cores in type…

Fig. 7.1 Hematoxylin & eosin (HE) statin shows abundant necrotic fibers and myophagocytosis (arrows), increased fiber size variation with many polygonal atrophic fibers, and endomysial and perimysial fibrosis. Alkaline phosphatase…

Fig. 12.1 Quadriceps muscle biopsy from the present patient. HE stain shows increased fiber size variation with a few atrophic and hypertrophic fibers, and numerous internal nuclei. Many fibers contain…

Fig. 17.1 Myofibrillar myopathy. (a) H&E stain. (b) Gomori trichrome stain. (c) NADH-TR stain. (d) ATPase stain at pH 9.4. (e) Desmin immunostain. (f) Granulofilamentous material on electron microscopy Final Diagnosis…