Fig. 1 Illustration of differential gene expression profiling in Huntington’s disease (HD) systems. In this approach, cumulative cellular events relating to the disease process are described by “molecular snapshots” that…
Fig. 1 ChIP-seq workflow. Major steps in experimental procedure include cell collection and cross-linking, sonication of chromatin to achieve desired fragment length, antibody pulldown, library preparation, and sequencing 2 Materials…
Fig. 1 A scheme of integration of biotechnologies and applications for development of personalized medicine The role of neurogenomics in the development of personalized neurology is shown schematically in Fig….
Year Discovery/landmark/reference Pregenomic era 1871 Discovery of nucleic acids 1889 Hugo de Vries postulated “pangene” to be a living, self-replicating unit of heredity. His postulation was adapted from Darwin’s “pangenesis”…
Fig. 1 A wet laboratory workflow for combining non-barcoded sample pooling and targeted re-sequencing Fig. 2 Overview of the bioinformatics MPS data analysis pipeline in targeted re-sequencing with pooled samples…
Fig. 1 Example experimental flowchart and data from a study utilizing laser capture microdissection and RNA-Seq. In this study, we exposed adult Fischer-344 rats either to their control home cage…
