Site Acute complication (<4 weeks after RT) Early-delayed complications (1–6 month after RT) Late-delayed complications (>6 month after RT) Brain • Acute encephalopathy • Somnolence syndrome • Worsening of pre-existing symptoms •…
Multifocal enhancing lesions Solitary enhancing lesion Solid Metastases Multifocal glioma Lymphoma Demyelination Granulomatous disease High-grade glioma Metastases Lymphoma Medullublastoma Ependymoma Cystic Metastases Infection (bacterial, fungal, parasitic) High-grade glioma Metastases…
Fig. 10.1 a Brain coronal section demonstrating a glioblastoma with necrosis and intratumoral hemorrhage, centered within the right anterior frontal white matter. There is prominent mass effect. b Microscopic image in…
Fig. 20.1 A general approach to suspected CNS infection in a patient immunocompromised by cancer and its therapies involves basic blood tests and an urgent imaging procedure, preferably MRI, before directed…
Acute or subacute encephalopathy Methotrexate Cisplatin Vinca alkaloids Mechlorethamine Procarbazine Cytosine Arabinoside (Ara-C) Fludarabine Gemcitabine Hydroxyurea Pentostatin Chlorambuicil Thiotepa (high dose) Ifosfamide Hexamethylmelamine Cyclophosphamide Etoposide Paclitaxel Docetaxel Doxorubicin (IT administration)…
Fig. 7.1 A 56 year old patient with a T1bN0MO melanoma, not on immunotherapy, presented with bilateral, asymmetric lower extremity and left upper extremity weakness with associated back pain and without significant…
Metastatic complications of breast cancer Central nervous system Cranial Parenchymal brain metastases Skull base metastases Dural metastases Spinal Intramedullary spinal cord metastases Spinal epidural metastases Leptomeningeal metastases Peripheral nervous system…
Fig. 30.1 a A 57-year-old man with acute lymphoblastic leukemia presented with right-sided Bell’s palsy, a left-sided vocal cord paralysis and an abducens nerve palsy on the right. T1-weighted MRI brain…
Fig. 33.1 Incidence of pediatric cancers. Age-adjusted and age-specific SEER cancer incidence rates, 2008–2012, all races, male and female, ages 0–19. (Created from data in Howlader N, Noone AM, Krapcho M,…
Fig. 26.1 CNS complications of choriocarcinoma. Representative images of an aneurysmal hemorrhage from choriocarcinoma. a, b CT head shows an intraparenchymal hemorrhage in the right temporoparietal lobe with mass effect. Axial…
