CSF Total Protein
Age (years) Lumbar total protein range (mg/L) Newborn <1,700 1–15 90–350 16–60 150–450 8.4 Interpretation Many acute inflammatory diseases of the CNS are characterized by a mild to moderate increase…
Techniques, Contraindications, and Complications of CSF Collection Procedures
Needle Comparison Advantages Disadvantages Length Short Children – Long Adults or obese patients Procedure more difficult Diameter Small Less complications, pain, discomfort, blood contaminations, medication, and medical assistance Slow flow,…
Importance of Pre-analytical Stability for CSF Biomarker Testing
Fig. 5.1 Flowchart of pre-analytical steps in CSF analysis and common variability factors influencing outcome measures To generate recommendations for pre-analytical procedures, a distinction can be made between analysis of…
Physiology and Constituents of CSF
Fig. 3.1 Relationship between CSF–serum ratio of blood (white circles) and brain-derived (black circles) compounds and their hydrodynamic radius under “steady-state” conditions (Modified according to Felgenhauer (1995)). Alb albumin, α2-M…
