Pharmacotherapy in Dementia with Lewy Bodies
Fig. 16.1 Mean changes from baseline in the (a) Mini-Mental State Examination and (b) Neuropsychiatric Inventory (NPI-10) in the exploratory RCT of donepezil in DLB [23] 16.2.2.3 Recently, we conducted…
Electroencephalography in DLB
Fig. 14.1 Electrode positions in international 10–20 system Conventionally, considerable time was required to quantitatively examine slow-wave activity by means of visual observation. Using NAT technology, however, it is possible…
Traditional Chinese Medicine for Treatment of Dementia
Fig. 17.1 Change in NPI score. NPI significantly improved in the YGS group (n = 27, from 37.9 ± 16.1 to 19.5 ± 15.6, mean ± SD; p < 0.001) but did not change significantly in the control group (n = 25)….
123I-Metaiodobenzylguanidine Myocardial Scintigraphy in Dementia with Lewy Bodies
Fig. 12.1 Chemical structures of MIBG and norepinephrine Fig. 12.2 Mechanism of MIBG accumulation in sympathetic nerve terminal. MIBG is uptaken to sympathetic nerve terminals via uptake-1, is transported to…
Molecular Biology of Dementia with Lewy Bodies
Fig. 4.1 Scientists who have worked alongside Michel Goedert in Cambridge – (from left) Valerie Buee-Sherrer, Tony Crowther, Ross Jakes, Maria Spillantini, Michel Goedert, Mike Smith, Molly Craxton and Masato…
Autonomic Symptoms in Dementia with Lewy Bodies
Fig. 9.1 In patients with Lewy body disease, Lewy bodies and Lewy neurites are observed in not only the central nervous system but also the peripheral autonomic nervous system. The…
Alpha-Synuclein in Cerebrospinal Fluid
Fig. 13.1 Extracellular soluble A-syn oligomers play an important role in both the development and progression of PD. (a) The cascade of A-syn aggregation. The A53T mutation promotes the formation…
Ventilatory Response to Hypercapnia in Dementia with Lewy Bodies
Fig. 15.1 Reduced respiratory response to hypercapnia The indices of VRH of the DLB patients, AD patients, and controls were 0.156 ± 0.10, 0.431 ± 0.04, and 0.466 ± 0.09, respectively (Fig. 15.2). VRH in DLB patients…
CT, MRI, SPECT, and PET in DLB
Fig. 10.1 (a–d) MRI findings of characteristic AD and DLB cases. (a) Probable AD case. Medial temporal lobe atrophy (MTA) is prominently evident bilaterally. (b) Probable DLB case. MTA is…
Dopamine Transporter Imaging
Fig. 11.1 Nigrostriatal dopaminergic synapse and targets of PET and SPECT ligands. Tyrosine is converted to L-DOPA by tyrosine hydroxylase. L-DOPA is then converted to dopamine, which is gathered into…
