Abstract Currently, 17 transcription factors are known to form the Krüppel-like factor (KLF) family. All transcription factors of the KLF family resemble the members of the specificity protein (Sp) family;…
Abstract The small non-coding RNAs are called microRNAs or miRNAs that play key roles in mRNA silencing as well as in post-transcriptional regulation of gene expression in eukaryotic cells. The…
Abstract Neuroblastoma is the most common malignancy in infancy and the most common extracranial solid tumor in the pediatric age group. There is only approximately 30%–40% long-term survival rates among…
Abstract This chapter introduces the molecular targeted therapies and immunotherapies currently in use to treat neuroblastoma, which is the most common extracranial solid tumor in children. It presents a clinical…
Abstract Antiangiogenic strategies are currently in use for the treatment of cancer, and the inhibition of angiogenesis could represent a powerful adjunct to traditional therapy of malignant tumors. Over the…
Abstract The management of neuroblastoma requires a multidisciplinary approach led by the pediatric surgeon. Surgical biopsy and resection are essential to characterize the tumor, stratify patient risk, and guide the…
Abstract More than 50% of patients with high-risk neuroblastoma will relapse despite intensive multi-modal therapy. Management of these patients is challenging, given disease heterogeneity, resistance, and organ toxicity. Recent advances…
Abstract In the cell, autophagy is the major regulatory catabolic mechanism responsible for the maintenance of cellular homeostasis. It is active at a basal level in all cell types, and…
Abstract Current therapeutic approaches for high-risk neuroblastoma include dose-intensive chemotherapy, surgical and radiotherapeutic interventions that are associated with long- and short-term toxicities. Immunotherapy utilizes mechanisms of action that are not…
Abstract Neuroblastoma is, at once, a common and a frequently deadly cancer seen almost exclusively in children. The prognosis for patients with neuroblastoma is best in those whose tumor burden…
