Physical Therapy and Rehabilitation in Patients with Degenerative Cerebellar Diseases: Current Evidence and Future Direction

Nov 3, 2016 by in NEUROLOGY Comments Off on Physical Therapy and Rehabilitation in Patients with Degenerative Cerebellar Diseases: Current Evidence and Future Direction

Fig. 10.1 Sustained increase of oxygenated hemoglobin (oxyHb) signals during treadmill walking in a patients with cerebellar ataxia. While oxyHb signals in the prefrontal cortex gradually decreased during treadmill walking…

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Significance of Mechanism-Oriented Research Toward Neuronal Protection Therapy Against Neurodegenerative Disorders ~ ZNRF1 E3 Ubiquitin Ligase as a Critical Mediator for Wallerian Degeneration and Neuronal Apoptosis

Nov 3, 2016 by in NEUROLOGY Comments Off on Significance of Mechanism-Oriented Research Toward Neuronal Protection Therapy Against Neurodegenerative Disorders ~ ZNRF1 E3 Ubiquitin Ligase as a Critical Mediator for Wallerian Degeneration and Neuronal Apoptosis

Insult Effect Axonal degeneration Neuronal apoptosis References 6OHDA Some axons preserved for ~11 days + − Sajadi et al. (2004) MPTP Enhances survival, prevents nigrostriatal axon degeneration, and attenuates neurotransmitter loss…

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Drug Development for Neurodegenerative Diseases

Nov 3, 2016 by in NEUROLOGY Comments Off on Drug Development for Neurodegenerative Diseases

Fig. 9.1 Abnormal protein misfolding and aggregation as the common molecular pathogenesis of neurodegenerative diseases. Most of the genetic mutations responsible for the inherited neurodegenerative diseases commonly render the mutant…

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Clinical Systems Neuroscience

Nov 3, 2016 by in NEUROLOGY Comments Off on Clinical Systems Neuroscience

Fig. 5.1 Clinical systems neuroscience consists of multi-layered sub-disciplines with different spatial scales: molecular neuroscience (nanometer), cellular neuroscience (micrometer), systems neuroscience and cognitive/behavioral neuroscience (millimeter to centimeter). Advances in non-invasive…

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Social Implementation of Neurodegenerative Disease Research and Neuroethics

Nov 3, 2016 by in NEUROLOGY Comments Off on Social Implementation of Neurodegenerative Disease Research and Neuroethics

© Springer Japan 2015Keiji Wada (ed.)Neurodegenerative Disorders as Systemic Diseases10.1007/978-4-431-54541-5_13 13. Social Implementation of Neurodegenerative Disease Research and Neuroethics Tamami Fukushi1   (1) Platform for Regenerative Medicine, Foundation for Biomedical Research and Innovation (FBRI), Kobe, Japan…

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Intermediate Phenotype Approach for Neuropsychiatric Disorders

Nov 3, 2016 by in NEUROLOGY Comments Off on Intermediate Phenotype Approach for Neuropsychiatric Disorders

Fig. 7.1 Two concepts of intermediate phenotype approach. Susceptibility genes for neuropsychiatric disorders do not directly encode for the clinical syndrome/behaviors. The abnormal behaviors observed in neuropsychiatric disorders are produced…

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Genetic Risk Factors for Neurodegenerative Diseases

Nov 3, 2016 by in NEUROLOGY Comments Off on Genetic Risk Factors for Neurodegenerative Diseases

Fig. 6.1 The genetic and environmental factors that contribute to the occurrence of neurodegenerative diseases. (Left) Disease defined by a mutation in a single gene (as observed in monogenic Mendelian…

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Brain–Peripheral Organ Communication

Nov 3, 2016 by in NEUROLOGY Comments Off on Brain–Peripheral Organ Communication

Fig. 2.1 A schematic diagram of two neural routes that mediate peripheral organ–brain interactions: (A) The afferent vagus–nucleus tract solitarii (NTS) axis. Information on the visceral organs is transmitted to…

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