Figure 24.1 Phases of development for a surrogate marker of progression in Parkinson’s disease (PD). Biomarker discovery leads to identification of species that are most often first studied in cross-sectional…
Figure 19.1 Deep-brain stimulation selection decision-making algorithm, based on CAPSIT criteria. Reproduced with permission from Duker AP, Espay AJ. Surgical Treatment of Parkinson Disease: Past, Present, and Future. Neurol Clin…
Figure 6.1 Structure of dopamine and rotigotine. Pharmacokinetics Rotigotine has a broad spectrum of action across the D1–D5 receptors (Table 6.3) [12]. This, particularly its D1 activity, is in theory…
Figure 16.1 Central pain pathways in Parkinson’s disease. Left: The lateral system is formed by the neospinothalamic, the neotrigeminothalamic, the cervical bundle and the beam of the dorsal horn whose…
Figure 3.1 (A) Expression of different glutamate receptor subtypes, demonstrating the complexity expected in any attempt to modulate glutamatergic neurotransmission. (B) Illustration of the corticostriatal circuits, demonstrating the role of…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 32 Lessons and challenges of trials involving ancillary therapies for the management of Parkinson’s disease Chris J. Hass, Elizabeth L. Stegemöller, Madeleine E. Hackney and…
Figure 31.1 Therapeutic approach to the common nonmotor symptoms of Parkinson’s disease. Sialorrhea Drooling is present in 80% of patients with PD and is secondary to disturbances in swallowing the…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 30 Lessons and challenges of trials for cognitive and behavioral complications of Parkinson’s disease Daniel Weintraub and Lama M. Chahine Introduction There has been increasing…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 28 Controversy: ablative surgery vs deep-brain stimulation in the management of Parkinson’s disease Gian D. Pal and Leo Verhagen Metman Introduction The concept of surgically…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 29 Controversy: midstage vs advanced-stage deep-brain stimulation in the management of Parkinson’s disease Mallory L. Hacker and David Charles Introduction Parkinson’s disease (PD) is a…
