PET Quantification in Neuropsychiatry
Fig. 2.1 Time-activity curves of a PET tracer targeting PDE10A (Van Laere et al. 2013) for the putamen, caudate nucleus, and thalamus. (a) represents an average SUV image (averaged over…
Psychiatric Disorders in Dementia
A. Development of multiple cognitive deficits A1. Memory problems (e.g., amnesia) A2. At least one or more of the following: Aphasia (language impairment) Apraxia (loss of the ability to execute…
Pharmacological Interventions That Have the Potential to Alter Neurotransmitter Levels in the Human Brain
Fig. 3.1 Validation of the neuronal origin of serotonin (5-HT) sampled by a microdialysis probe (exposed tip length, 1 mM) in the central nucleus of the amygdala (CeA) of freely…
Brain SPECT in the Impulsive-Aggressive Dog
Fig. 26.1 Brain perfusion SPECT in a normal dog (horizontal/transverse slices). The colour scale gives information on the intensity of radioactivity registered in different areas: highest uptake is related with…
Impulsivity Imaging
, Nozipho Nyakale1 and Mike Sathekge1 (1) Nuclear Medicine Department, Steve Biko Academic Hospital, University of Pretoria, Voortrekkers Road and Malan Street, Capital Park, Pretoria, South Africa Mike Sathekge Email: mike.sathekge@up.ac.za…
PET and SPECT in Sleep Disorders
Study Imaging technique employed Target Number of patients/controls Patients receiving treatment/total number of patients Results Sudo et al. (1998) PET 11C-MPB ACh 11/21 0/11 No change Derry et al. (2006)…
Dissociative Identity Disorder and Fantasy Proneness: A Positron Emission Tomography Study of Authentic and Enacted Dissociative Identity States
Fig. 16.1 The study-specific general linear model as created in SPM Intermezzo: The Study’s General Linear Model The water-activation-PET data was analysed in an imaging-specific data-analysis program called Statistical Parametric…
SPECT and PET Imaging of Apathy
For a diagnosis of Apathy the patient should fulfil the criteria (A), (B), (C) and (D) (A) Loss of or diminished motivation in comparison to the patient’s previous level of…
OCD: Serotonergic Mechanisms
Fig. 17.1 A schematic of the similar metabolic pathways of the 5-HT precursor tryptophan and the analogous radioisotope α-[11C]MTrp. PNS peripheral nervous system, CNS central nervous system, BBB blood-brain barrier,…
Molecular Imaging Studies in Stimulant Addiction: A Cross-Species Perspective
Fig. 22.1 Schematic illustration showing the major co-morbidities associated with adult attention deficit hyperactivity disorder, including alcohol and drug dependence (From Kessler et al. (2006)) 22.2 SPECT/PET Studies in Addiction…
