Systems Phenomics

Dec 16, 2016 by in NEUROLOGY Comments Off on Systems Phenomics

Fig. 7.1 Magnetic resonance images of a 24-week-old foetus. From Anblagan et al. (unpublished observation) The same scanner can be used for acquiring different types of images by changing the exact…

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Personalized Preventive Medicine

Dec 16, 2016 by in NEUROLOGY Comments Off on Personalized Preventive Medicine

Fig. 10.1 Healthy and total (healthy + unhealthy) life expectancy at birth in England, 1994–1999. Adapted from the Office for National Statistics licensed under the Open Government Licence v.1.0. From Bajekal (2005) Given…

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Challenges

Dec 16, 2016 by in NEUROLOGY Comments Off on Challenges

Fig. 9.1 Meta-analysis of the effects of breastfeeding on cognitive development. Numbers indicate co-variate-adjusted mean differences (and 95 % confidence intervals) for matched composite observations across 11 different studies. Reprinted from Anderson…

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Genomics

Dec 16, 2016 by in NEUROLOGY Comments Off on Genomics

Fig. 4.1 DNA–chromatin complexes a binding of basic histone proteins, b a nucleosome—two turns of DNA wrapped around core histones, c electron micrograph of nucleosomal filaments, d cross section of a…

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Enviromics

Dec 16, 2016 by in NEUROLOGY Comments Off on Enviromics

Fig. 3.1 An individual and his/her internal, social and physical environments Because the cells of various tissues are exposed to hundreds of small molecules (metabolites), hormones and enzymes circulating through the…

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Terms and Concepts

Dec 16, 2016 by in NEUROLOGY Comments Off on Terms and Concepts

Fig. 1.1 Breastfeeding and general intelligence: mediation and moderation From this pattern of “transactions”, we conclude that exposure (breastfeeding) affects the outcome (general intelligence) by influencing mediator 1 (brain growth inferred…

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Epigenomics

Dec 16, 2016 by in NEUROLOGY Comments Off on Epigenomics

Fig. 5.1 Agouti mice. From Morgan et al. (1999) Such trans-generational epigenetic transmission is likely to vary with the number of subsequent generations. For example, certain epigenetic modifications of histones in…

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Cohorts

Dec 16, 2016 by in NEUROLOGY Comments Off on Cohorts

Study Age (years) MRI Brain + ALSPAC 18–21 500 + Generation R: Wave 1 5–7 1,000 + Generation R: Wave 2 10–12 5,000* IMAGEN 13.5–15.5 2,000 + NFBC1986 25–27 900…

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Molecular Phenomics

Dec 16, 2016 by in NEUROLOGY Comments Off on Molecular Phenomics

Fig. 6.1 Genome, Transcriptome, Proteome, Metabolome and Lipidome (from http://en.wikipedia.org/wiki/Lipidomics). Transcriptome refers to the collection of all genes expressed in a given tissue at a given time. Similarly, a proteome is…

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History of the Key Disciplines

Dec 16, 2016 by in NEUROLOGY Comments Off on History of the Key Disciplines

Fig. 2.1 (a) Number of citations per year indexed by Medline from 1966 to 2005 under subject headings related to important non-infectious, neuropsychiatric, infectious and sexually transmitted diseases. (b) Number of…

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