Fig. 16.1 Schematic of experimental design. Shown are the steps using phMRI to identify common brain activity in drugs at risk, and those for treating suicidal ideation and self-harm. Finding the…
Fig. 3.1 Regulatory history and perspectives on SIB assessment. a 1991–2008 b 2009–2013 European Regulators were the first to post restrictions on the use of antidepressants. In 2003, the UK Medicines…
Fig. 2.1 Public health burden of suicidal behavior among adults aged ≥18 years—United States, 2008 (Source Crosby et al. 2011). *Source CDC’s National Vital Statistics System. All rates per 100,000 population. § Agency…
Validity Description Challenges Face The animal model should recapitulate one or more of the core symptoms of the disease Difficult to replicate the features of suicide in a non-human species…
Fig. 4.1 Suicidal ideation and behavior categories and definitions (FDA 2012) Suicidal ideation and a history of suicidal behavior are among the most salient short- and long-term risk factors for suicide…
Fig. 17.1 miRNA biogenesis. miRNAs are encoded in the genome (inter or intragenis) and transcribed by RNA polymerase II to generate primary microRNA (pri-miRNA). These pri-miRNAs are taken up by Drosha/DGCR8,…
© Springer International Publishing Switzerland 2014Keri E. Cannon and Thomas J. Hudzik (eds.)Suicide: Phenomenology and Neurobiology10.1007/978-3-319-09964-4_14 14. Cognitive Therapy with Suicidal Patients Michael E. Thase1 (1) Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania and…
© Springer International Publishing Switzerland 2014Keri E. Cannon and Thomas J. Hudzik (eds.)Suicide: Phenomenology and Neurobiology10.1007/978-3-319-09964-4_15 15. Human Imaging Studies of Suicidal Behavior and its Risk Factors Kees van Heeringen1 , Stefanie Desmyter1 and Stijn Bijttebier1 (1) Unit for Suicide…
© Springer International Publishing Switzerland 2014Keri E. Cannon and Thomas J. Hudzik (eds.)Suicide: Phenomenology and Neurobiology10.1007/978-3-319-09964-4_13 13. Psychotherapeutic Treatment Approaches for Suicidal Individuals Megan S. Chesin1, 2 , Sadia Chaudhury2 and Barbara Stanley1, 2 (1) Department of Psychiatry, Columbia University…
Fig. 12.1 Putative targets in the neurobiology of suicide. Adapted from:(Mathews et al. 2013). BDNF brain-derived neurotrophic factor; CREB cyclic AMP-response element binding protein; GABA gamma-aminobutyric acid; HPA hypothalamic-pituitary-adrenal; PLC Phospholipase…
