GABAA Receptor α1 Subunit (Gabra1) Knockout Mice: Review and New Results
Fig. 4.1. (a) A schematic of the 5′ end of the Gabra1 locus. As described in the text, a yeast-mediated recombination step replaced the genomic region to be deleted with…
The Utility of Genetically Modified Animals in Modeling OCD-Spectrum Disorders
Fig. 7.1. Considered an anxiety spectrum disorder, obsessive-compulsive disorder (OCD) shows clinical heterogeneity and substantial overlap with other psychiatric disorders The Obsessive-compulsive spectrum disorders (OCSD) is a grouping of human…
Mutant and Transgenic Tools in Modeling Schizophrenia
PubMedCrossRef 6. Chen J, Lipska BK, Weinberger DR (2006) Genetic mouse models of schizophrenia: from hypothesis-based to susceptibility gene-based models. Biol Psychiatry 59:1180-1188PubMedCrossRef 7. O’Tuathaigh CMP, Babovic D, O’Meara G…
Environmental Enrichment and Gene–Environment Interactions in Mouse Models of Brain Disorders
CrossRefPubMed 2. van Praag H, Kempermann G, Gage FH (2000) Neural consequences of environmental enrichment. Nat Rev Neurosci 1:191-198CrossRefPubMed 3. Grote HE, Hannan AJ (2007) Regulators of adult neurogenesis in…
Genetic Animal Models of Depression
CrossRefPubMed 2. Levinson DF (2006) The genetics of depression: a review. Biol Psychiatry 60:84-92CrossRefPubMed 3. Zimmermann P, Bruckl T, Lieb R, Nocon A, Ising M, Beesdo K et al (2008)…
Genetic Animal Models of Anxiety
CrossRefPubMed 7. Vieweg WV, Julius DA et al (2006) Posttraumatic stress disorder: clinical features, pathophysiology, and treatment. Am J Med 119(5):383-390CrossRefPubMed 8. Phobia AES (2007) U. S. D. o. H….
Rat Mutants with Lateralized Rotational Behavior for Studying Disturbances in Cerebral Asymmetries and Their Involvement in Brain Disorders
Fig. 3.1. Lateralized circling behavior of ci2/ci2 and ci3/ci3 rats. All data are shown as means ± SEM. (a) illustrates the average number of rotations of 88 ci2/ci2 rats in…
Investigating Rett Syndrome Through Genetic Mouse Models: Presymptomatic, Clearly Symptomatic Phases, and Innovative Therapeutic Approaches
In the MeCP2Bird model (18), male and female mice appeared normal till the third postnatal week, afterward both sexes developed gross abnormalities (with sex-dimorphic time course) consisting of a stiff,…
Knockout and Mutant Rats
Fig. 2.1. Social play behavior in periadolescent (aged between 28 and 35 days) rats. SERT−/− rats played significantly less compared to SERT+/+ rats. Social aggression has also been studied in…
Mutant and Transgenic Zebrafish in Modeling Neurobehavioral Disorders
Fig. 1.1. Wild type (top) and long-fin mutant (bottom) zebrafish. Additionally, a zebrafish model of Huntington’s disease (HD) was generated through a reverse genetics technique, using a morpholino (antisense morpholino-modified…
