Introduction Radiotherapy has been successfully used for many decades to control tumor growth and hormonal hypersecretion of pituitary adenomas. Although initially used as a primary treatment for these neoplasms, in…
Introduction Primary pituitary carcinomas are rare tumors defined as primary adenohypophyseal neoplasms that have undergone cerebrospinal or systemic metastasis. They constitute 0.1% to 0.2% of all pituitary tumors and their…
Introduction Since the repopularization of the transsphenoidal approach by Guiot and Hardy, most surgeons have adopted this technique as the primary method for the removal of pituitary adenomas. Following the…
Introduction Cushing’s syndrome is an endocrinopathy, resulting in distinctive clinical features and associated systemic changes. Cushing’s disease is the name given to the disorder when it is caused by a…
Introduction Since the first attempts to remove pituitary tumors through the transsphenoidal approach almost a century ago, it became clear that one of the main challenges was to create an…
Introduction Acromegaly is a medical condition defined by elevated serum growth hormone (GH) levels almost always secondary to hypersecretion by cells of the anterior pituitary. Descriptions of individuals consistent with…
Introduction Tumors of the pituitary gland and sellar region represent approximately 10% to 15% of all brain tumors. Several types of tumors may involve the sellar region, reflecting its complex…
Introduction The sellar and parasellar region is a complex and relatively small intersection of endocrine, neural, vascular, meningeal, and skeletal structures. Various types of mass lesions, inflammatory processes, cysts, and…
Introduction Performing the transsphenoidal procedure requires the neurosurgeon to master a unique set of surgical techniques. While the ultimate goal rests with the hypophysis and neuraxis, the surgical approach mandates…
Introduction The transsphenoidal approach to pituitary tumors represents a fascinating chronicle in surgical history. The result of this evolution and continued refinement of the transsphenoidal approach is that pituitary tumors…
