For those with peri-ictal depression, improved seizure control may be a sufficient treatment. For patients with resistant peri-ictal depression, interictal MDD, persistent depressive disorder, or IDD, antidepressant treatment is indicated….
In a study examining the distribution of 600 focal seizures across the sleep–wake cycle recorded during video–electroencephalogram (EEG) evaluations, 43% were found to arise from sleep, the majority from non–rapid…
Figure 66.1. Zonisamide. MECHANISM OF ACTION There are several pharmacologic effects of zonisamide that may be responsible for its activity as an AED. Results from several studies demonstrate the most…
The Regulatory Requirements The first seizure-related car crash was reported near the turn of the 19th century. Since then, regulatory authorities have placed restrictions on driving for a person with…
Related posts: The Natural History of Seizures Hormones, Catamenial Epilepsy, Sexual Function, and Reproductive and Bone Health in Epilepsy Epilepsy in the Setting of Inherited Metabolic and Mitochondrial Disorders Sleep…
Related posts: The Natural History of Seizures Hormones, Catamenial Epilepsy, Sexual Function, and Reproductive and Bone Health in Epilepsy Epilepsy in the Setting of Inherited Metabolic and Mitochondrial Disorders Sleep…
Figure 55.1. Chemical structure of gabapentin, pregabalin, and gabapentin enacarbil. The mechanism of action of gabapentinoids differs from that of other antiepileptic drugs (AEDs). Contrary to initial belief, they do…
For an up-to-date review of an individual metabolic disease or to find a lab where an analyte or gene test can be sent, we recommend visiting the NIH GeneReviews site…
Figure 59.1. 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl) benzonitrile hydrate, M.W. 349.38 (perampanel). PERAMPANEL PHARMACOLOGY Glutamate is the major excitatory neurotransmitter in the CNS. Fast glutaminergic transmission is mediated predominantly by NMDA and AMPA receptors…
