CHAPTER 226 Intrathecal Baclofen Therapy for Cerebral Palsy Leland Albright Baclofen, chlorophenyl, cyclohexyl γ-aminobutyric acid, is a GABAB agonist originally synthesized for evaluation as an anticonvulsant. It was found to…
CHAPTER 228 Dystonia in Children Leland Albright Definition and Pathophysiology Dystonia is an involuntary movement disorder characterized by sustained or intermittent muscle contractions that cause twisting and repetitive movements, abnormal…
CHAPTER 107 Gene- and Viral-Based Therapies for Gliomas Kaveh Asadi-Moghaddam, E. Antonio Chiocca Advances in understanding gene structure/function and in the capacity to manipulate their expression have set the stage…
CHAPTER 101 Growth Factors in Glial Tumors Abhijit Guha, David Omahen This last part of surgery, namely, operations, is a reflection on the healing art; it is a tacit acknowledgement…
CHAPTER 94 Neuroprosthetics Jacob Aacob Donoghue, Jacob H. Bagley, Gerhard M. Friehs, Vasilios A. Zerris Hundreds of thousands of people are afflicted by injuries or disorders that disrupt input-output pathways…
CHAPTER 177 Dandy-Walker Syndrome Ondrej Choutka, Francesco T. Mangano History Dandy-Walker syndrome (DWS) represents a congenital malformation characterized by agenesis or hypoplasia of the cerebellar vermis, cystic dilation of the…
CHAPTER 398 Pregnancy and the Vascular Lesion Khoi D. Than, B. Gregory Thompson, Jr. A cerebrovascular lesion in the setting of pregnancy presents a unique neurosurgical dilemma in which the…
CHAPTER 97 Brain Tumor Immunology and Immunotherapy Roberta P. Glick, Terry Lichtor, Amy B. Heimberger A Brief History of Immunotherapy About 1790, Jenner made the observation that milkmaids were protected…
CHAPTER 379 Infectious Intracranial Aneurysms Scott A. Meyer, Joshua B. Bederson The first description of an aneurysm of infectious etiology arising within the intracranial circulation was provided by Church in…
CHAPTER 6 Neurons and Neuroglia Bruce D. Trapp, Karl Herrup The nervous system is structurally and functionally the most complicated organ of the human body. Normal brain function depends on…
