Sleep and Epilepsy
In a study examining the distribution of 600 focal seizures across the sleep–wake cycle recorded during video–electroencephalogram (EEG) evaluations, 43% were found to arise from sleep, the majority from non–rapid…
Zonisamide
Figure 66.1. Zonisamide. MECHANISM OF ACTION There are several pharmacologic effects of zonisamide that may be responsible for its activity as an AED. Results from several studies demonstrate the most…
Driving and Social Issues in Epilepsy
The Regulatory Requirements The first seizure-related car crash was reported near the turn of the 19th century. Since then, regulatory authorities have placed restrictions on driving for a person with…
Corpus Callosotomy and Multiple Subpial Transection
Related posts: The Natural History of Seizures Hormones, Catamenial Epilepsy, Sexual Function, and Reproductive and Bone Health in Epilepsy Epilepsy in the Setting of Inherited Metabolic and Mitochondrial Disorders Sleep…
MRI Postprocessing Techniques and Clinical Applications
Related posts: The Natural History of Seizures Hormones, Catamenial Epilepsy, Sexual Function, and Reproductive and Bone Health in Epilepsy Epilepsy in the Setting of Inherited Metabolic and Mitochondrial Disorders Sleep…
Gabapentin and Pregabalin
Figure 55.1. Chemical structure of gabapentin, pregabalin, and gabapentin enacarbil. The mechanism of action of gabapentinoids differs from that of other antiepileptic drugs (AEDs). Contrary to initial belief, they do…
Epilepsy in the Setting of Inherited Metabolic and Mitochondrial Disorders
For an up-to-date review of an individual metabolic disease or to find a lab where an analyte or gene test can be sent, we recommend visiting the NIH GeneReviews site…
Perampanel
Figure 59.1. 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl) benzonitrile hydrate, M.W. 349.38 (perampanel). PERAMPANEL PHARMACOLOGY Glutamate is the major excitatory neurotransmitter in the CNS. Fast glutaminergic transmission is mediated predominantly by NMDA and AMPA receptors…
Carbamazepine, Oxcarbazepine, and Eslicarbazepine
Related posts: The Natural History of Seizures Hormones, Catamenial Epilepsy, Sexual Function, and Reproductive and Bone Health in Epilepsy Gabapentin and Pregabalin Sleep and Epilepsy Outcome and Complications of Epilepsy…
