Current Standards of Care in Glioblastoma Therapy
Introduction With an incidence of 3 to 5 per 100,000, glioblastoma fulfills the criteria of a rare cancer. Despite this, glioblastoma is the most common and most aggressive primary brain…
Epidemiology of Glioblastoma and Trends in Glioblastoma Survivorship
Incidence of glioblastoma Gliomas are the most common type of malignant brain tumor in adults. Of the gliomas, glioblastoma (astrocytoma grade IV) is the most common, and represents approximately 27%…
Multimodality Targeting of Glioma Cells
Acknowledgments This work was supported by National Institutes of Health grants R00HL103792 and R01NS094533 , University of Pennsylvania Neuro-oncology Innovation Award, and McCabe Award (to Y. Fan). Glioma is the…
Radiographic Detection and Advanced Imaging of Glioblastoma
Acknowledgments The authors would like to acknowledge our colleagues and teachers in neuroradiology at the University of Pennsylvania for their insights on brain tumor imaging, particularly Drs Ronald Wolf, Linda…
Principles and Tenets of Radiation Treatment in Glioblastoma
Standard-of-care radiation regimens Historical Context of Radiation Therapy and Dose Historically, standard treatment for glioblastoma (GBM) was surgical resection alone. The first randomized trial to show a survival benefit with…
Chemotherapeutics and Their Efficacy
Introduction Glioblastoma (GBM), the most common primary brain malignancy, carries a poor prognosis and has therefore been the subject of numerous studies attempting to improve outcomes. Although a plethora of…
Antiangiogenic Therapy for Glioblastoma
Introduction This chapter reviews the history of angiogenesis and how it was recognized as an essential mechanism for tumor establishment and growth. From the initial recognition of tumor vascularity to…
Cerebrovascular Anatomy and Implications for Arteriovenous Malformation Treatment
1 Cerebrovascular Anatomy and Implications for Arteriovenous Malformation Treatment W. Caleb Rutledge and Michael T. Lawton Abstract Arteriovenous malformations (AVMs) are complex vascular lesions. The Spetzler–Martin system and Lawton–Young supplementary grading…
Radiosurgery for Dural Arteriovenous Fistulas: Indications and Outcomes
26 Radiosurgery for Dural Arteriovenous Fistulas: Indications and Outcomes Cheng-Chia Lee, Huai-Che Yang, Hsiu-Mei Wu, Wen-Yuh Chung, Wan-Yuo Guo, and David H.C. Pan Abstract Stereotactic radiosurgery using the Gamma Knife or…
Surgical Treatment of Cerebellar Arteriovenous Malformations
15 Surgical Treatment of Cerebellar Arteriovenous Malformations João Paulo Almeida, Vitor Yamaki, Mateus Reghin Neto, Feres Chaddad Neto, Albert Rhoton Jr., and Evandro de Oliveira Abstract Cerebellar arteriovenous malformations (AVMs) represent…
