Acute or subacute encephalopathy Methotrexate Cisplatin Vinca alkaloids Mechlorethamine Procarbazine Cytosine Arabinoside (Ara-C) Fludarabine Gemcitabine Hydroxyurea Pentostatin Chlorambuicil Thiotepa (high dose) Ifosfamide Hexamethylmelamine Cyclophosphamide Etoposide Paclitaxel Docetaxel Doxorubicin (IT administration)…
Fig. 7.1 A 56 year old patient with a T1bN0MO melanoma, not on immunotherapy, presented with bilateral, asymmetric lower extremity and left upper extremity weakness with associated back pain and without significant…
Metastatic complications of breast cancer Central nervous system Cranial Parenchymal brain metastases Skull base metastases Dural metastases Spinal Intramedullary spinal cord metastases Spinal epidural metastases Leptomeningeal metastases Peripheral nervous system…
Fig. 30.1 a A 57-year-old man with acute lymphoblastic leukemia presented with right-sided Bell’s palsy, a left-sided vocal cord paralysis and an abducens nerve palsy on the right. T1-weighted MRI brain…
Fig. 33.1 Incidence of pediatric cancers. Age-adjusted and age-specific SEER cancer incidence rates, 2008–2012, all races, male and female, ages 0–19. (Created from data in Howlader N, Noone AM, Krapcho M,…
Fig. 26.1 CNS complications of choriocarcinoma. Representative images of an aneurysmal hemorrhage from choriocarcinoma. a, b CT head shows an intraparenchymal hemorrhage in the right temporoparietal lobe with mass effect. Axial…
Time point Complication Stem cell harvest Intracranial hypotension due to entry into subarachnoid space during bone marrow aspiration Worsening neurologic manifestations of underlying autoimmune syndrome, possibly related to G-CSF Conditioning…
Hematologic disorder Most common monoclonal protein type Neuropathy phenotype Autonomic involvement Helpful laboratory markers Monoclonal gammopathy of undetermined significance IgM kappa Length-dependent, sensory predominant, demyelinating with prolonged distal latencies –…
Fig. 28.1 Histological analysis of perineural invasion of HNSCC. Perineural (a) and intraneural invasions (b) by squamous cell carcinoma of the head and neck (H&E staining). White dotted lines indicate the…
Agent Therapeutic target(s)/mechanism of action Use(s) in cancer treatment Common neurologic toxicities (≥10% of patients) Rare neurologic toxicities (<10%) Monoclonal antibodies Bevacizumab VEGF-A Metastatic colorectal cancer, nonsquamous NSCLC, platinum-resistant ovarian…
