Animal model MES PTZ Kindling DBA/2 mice GAERS rats Human seizure/epilepsy type Generalized tonic-clonic seizures Generalized absence seizures Partial seizures (limbic) Generalized tonic-clonic, reflex seizures, SUDEP Generalized absence seizures Animal…
© Springer Science+Business Media LLC 2017Mohamad Z. Koubeissi and Nabil J. Azar (eds.)Epilepsy Board Review10.1007/978-1-4939-6774-2_18 18. Dietary Therapies Amy Kao1 (1) Center for Neurosciences and Behavioral Medicine, Children’s National Health System, 111 Michigan Ave NW, Washington,…
AED Felbamate Gabapentin Lamotrigine Topiramate Tiagabine Levetiracetam Protein bindinga Low Low Intermediate Low High Low Half-lifeb Intermediate Short Intermediate Intermediate Short Short Metabolism ~50% None Extensive ~30% Extensive ~30% Not…
AED Phenytoin Carbamazepine Oxcarbazepine MHD Phenobarbital Valproate Ethosuximide Protein bindinga High Intermediate Low Low High Low Half-lifeb Intermediate (can become long in toxicity) Intermediate Short Long Intermediate Long Metabolism Extensive,…
Syndrome Genetic test Inheritance Comment (a) Syndromes beginning in the 1st year of life Benign familial neonatal seizures KCNQ2 KCNQ3 AD M-channel subunit of voltage-gated potassium channel Seizure onset often…
© Springer Science+Business Media LLC 2017Mohamad Z. Koubeissi and Nabil J. Azar (eds.)Epilepsy Board Review10.1007/978-1-4939-6774-2_12 12. Imitators of Epilepsy Dewi Frances T. Depositario-Cabacar1 and Nabil J. Azar2 (1) Department of Neurology and Pediatrics, Children’s National Medical Center, George Washington University,…
© Springer Science+Business Media LLC 2017Mohamad Z. Koubeissi and Nabil J. Azar (eds.)Epilepsy Board Review10.1007/978-1-4939-6774-2_11 11. Seizures and Epilepsy in Early Life Adam L. Hartman1 (1) Neurology & Pediatrics, Johns Hopkins Medicine, 600 N. Wolfe St., Meyer…
© Springer Science+Business Media LLC 2017Mohamad Z. Koubeissi and Nabil J. Azar (eds.)Epilepsy Board Review10.1007/978-1-4939-6774-2_10 10. Electro-Clinical Syndromes by Age of Onset—Childhood, Adolescence, and Adult Tesfaye Zelleke1 (1) Department of Neurology, Children’s National Medical Center, 111…
Sign Lateralization of hemisphere Dystonic limb posturing Contralateral Head turning (early) Ipsilateral Head turning (late and versive, in transition to generalization) Contralateral Figure of 4 sign Contralateral Todd’s paralysis Contralateral Focal…
Fig. 12.1 Ischemic lesion volume is reduced and functional improvement is observed after human MSC (hMSC) injection. MRI imaging (a) of the rat brain at various times after systemic infusion…
