Animal models 5-HT-related abnormalities Region References Developmental hyperserotonemia model (DHS) Increase Whole (nonspecific 5-HT receptors agonist) [37, 38, 113] VPA treatment for embryo Decrease/Increase 5-HT Abnormal migration of 5-HT neurons…
© Springer Science+Business Media New York 2015Pierre L. Roubertoux (ed.)Organism Models of Autism Spectrum DisordersNeuromethods10010.1007/978-1-4939-2250-5_12 12. Zebrafish Social Behavior Testing in Developmental Brain Disorders Christine Buske1 (1) Papers/Springer SBM, 236 Gray’s Inn Road – Floor…
Fig. 1 Chromatin structure is a dynamic structure that contributes to gene regulation. Heterochromatin is highly compacted and usually associated with silenced genes while euchromatin corresponds to actively transcribed genes….
© Springer Science+Business Media New York 2015Pierre L. Roubertoux (ed.)Organism Models of Autism Spectrum DisordersNeuromethods10010.1007/978-1-4939-2250-5_10 10. Communication and Language in Animals Gene S. Fisch1 (1) Department of Epidemiology & Health Promotion, NYU Colleges of Dentistry &…
Fig. 1 The translational approach Organism models are used in the second and third stages. The identification of infectious, traumatic, and genetic events causing a disorder is initially done on…
Plate 10.1 A. africanus: Sts 5 (Sterkfontein, South Africa) Plate 10.2—P. aethiopicus: KNM WT-17000 (West Turkana, Kenya) Plate 10.2 P. aethiopicus: KNM WT-17000 (West Turkana, Kenya) Plate 10.3—P. boisei s.s.: OH 5 (Olduvai Gorge,…
Fig. 9.1 Structural MRI. a MRI scanner. Image credit Jan Ainali, Wikimedia Commons. b T1-weighted MRI scan of human brain (left) and chimpanzee brain (right) Strengths Structural MRI’s main strength is…
Fig. 4.1 Genes and traits are linked by multiple relationships involving pleiotropy and poligeny. Furthermore, genes and traits have intrinsic patterns of integration and modularity. Finally, both systems are susceptible to…
Fig. 3.1 Natural endocast of the Taung child, an Australopithecus africanus fossil from South Africa. a Photograph of the original specimen. b Computed-tomographic (CT) scan of the original fossil. The frontal…
Fig. 5.1 Hominin brain size evolution. Endocranial volume (EV) in milliliters is plotted against geological age of hominin fossils (mya, million years ago): gracile Australopithecines (green triangles), robust Australopithecines (black triangles),…
