Fig. 1 Induced pluripotent stem cells strategy to orient cell development towards differentiated neurons Taking fibroblasts in patients with a genetic disease, transforming the adult cells into iPSCs and reprogramming…
Fig. 1 The figure summarizes neurobiological processes that have been found to be abnormal in mouse models of tuberous sclerosis and that could contribute to the neuropsychiatric manifestations associated with…
Fig. 1 Schematic representation of the Mecp2 gene and localization of the modifications made to engineer Mecp2-deficient mouse models. See text for details Hundreds of MECP2 mutations are known in…
Animal models 5-HT-related abnormalities Region References Developmental hyperserotonemia model (DHS) Increase Whole (nonspecific 5-HT receptors agonist) [37, 38, 113] VPA treatment for embryo Decrease/Increase 5-HT Abnormal migration of 5-HT neurons…
© Springer Science+Business Media New York 2015Pierre L. Roubertoux (ed.)Organism Models of Autism Spectrum DisordersNeuromethods10010.1007/978-1-4939-2250-5_12 12. Zebrafish Social Behavior Testing in Developmental Brain Disorders Christine Buske1 (1) Papers/Springer SBM, 236 Gray’s Inn Road – Floor…
Fig. 1 Chromatin structure is a dynamic structure that contributes to gene regulation. Heterochromatin is highly compacted and usually associated with silenced genes while euchromatin corresponds to actively transcribed genes….
© Springer Science+Business Media New York 2015Pierre L. Roubertoux (ed.)Organism Models of Autism Spectrum DisordersNeuromethods10010.1007/978-1-4939-2250-5_10 10. Communication and Language in Animals Gene S. Fisch1 (1) Department of Epidemiology & Health Promotion, NYU Colleges of Dentistry &…
Fig. 1 The translational approach Organism models are used in the second and third stages. The identification of infectious, traumatic, and genetic events causing a disorder is initially done on…
Plate 10.1 A. africanus: Sts 5 (Sterkfontein, South Africa) Plate 10.2—P. aethiopicus: KNM WT-17000 (West Turkana, Kenya) Plate 10.2 P. aethiopicus: KNM WT-17000 (West Turkana, Kenya) Plate 10.3—P. boisei s.s.: OH 5 (Olduvai Gorge,…
Fig. 9.1 Structural MRI. a MRI scanner. Image credit Jan Ainali, Wikimedia Commons. b T1-weighted MRI scan of human brain (left) and chimpanzee brain (right) Strengths Structural MRI’s main strength is…
