Drug Trials in Neuroprotection
Trial (phase) Goal Drug Indication Primary outcome Secondary outcomes Alpha error Power Effect size Sample per arm Status Ref/NCT ACTION (RCT Phase II) Primary neuroprotection I: Amiloride C: Placebo iAON…
OCT Findings in Neuromyelitis Optica Spectrum Disorders
Fig. 6.1 Peripapillary and macular OCT scan from a healthy control (HC; female 30 years old), a multiple sclerosis associated optic neuritis eye (MSON eye; female 32 years old), and…
Monitoring Treatment in Multiple Sclerosis
Fig. 11.1 This is a spectral domain OCT analysis of peripapillary retinal nerve fiber layer (RNFL) thickness in a multiple sclerosis patient with prior left MSON. The RNFL thickness in…
OCT and Early MS: Clinically Isolated Syndromes (CIS)
© Springer International Publishing Switzerland 2016Axel Petzold (ed.)Optical Coherence Tomography in Multiple Sclerosis10.1007/978-3-319-20970-8_7 7. OCT and Early MS: Clinically Isolated Syndromes (CIS) Fiona Costello1 (1) Departments of Clinical Neurosciences and Surgery (Ophthalmology), University of Calgary,…
Introduction: Clinical Application of OCT in Multiple Sclerosis
© Springer International Publishing Switzerland 2016Axel Petzold (ed.)Optical Coherence Tomography in Multiple Sclerosis10.1007/978-3-319-20970-8_1 1. Introduction: Clinical Application of OCT in Multiple Sclerosis Sven Schippling1 (1) Neuroimmunology and Multiple Sclerosis Research Section, Department of Neurology, University…
Anatomy of the Retina and the Optic Nerve
Fig. 2.1 Retinal layers as they appear on spectral domain optical coherence tomography (Reprinted with permission from Staurenghi et al. [16]) Layer 1: Retinal Pigment Epithelium Histologically, the retinal pigment…
Vascular Disease
William C. Barrow, MD CHAPTER CONTENTS •Overview •Ischemic Stroke ◦Emergent Evaluation and Management – IV Thrombolytics – Special Considerations in IV tPA therapy – Endovascular Therapy – IV Heparin –…
Toolkit—Difficult Encounters
html xmlns=”http://www.w3.org/1999/xhtml”> 42 Toolkit Difficult Encounters Karl E. Misulis, MD, PhD and E. Lee Murray, MD CHAPTER CONTENTS •Brain Death •Persistent Vegetative State •End of Life Care •Lack of Good…
Psychiatric Disorders
E. Lee Murray, MD CHAPTER CONTENTS •Overview •Psychosis •Hospital Delirium •Catatonia •Serotonin Syndrome •Neuroleptic Malignant Syndrome •Conversion Disorder OVERVIEW Neurology consultation in patients with psychiatric conditions is usually related to…
Developmental and Genetic Disorders
E. Lee Murray, MD CHAPTER CONTENTS •Developmental Disorders ◦Chiari Malformation ◦Syringomyelia and Syringobulbia ◦Disorders of Neuronal Migration •Genetic Disorders ◦Hereditary Neuropathies ◦Hereditary Neuropathy with Pressure Palsy ◦Neurofibromatosis ◦Hereditary Spastic Paraparesis…
