Common Reasons for Psychiatric Consultation
Year 2012 2011 Suspected Depression and/or suicidal ideation 356 (28 %) 325 (27 %) Depression 176 (14 %) 166 (14 %) Suicide attempt or ideation 80 (14 %) 159 (13…
Psychiatric Consultation in the Emergency Setting
Acute <48 h Subacute <1 month Gradual <6 months Insidious 6+ months 5.2.4.1.2 Age Children birth to 12 years Teens 13–16 Young adults 17–25 Adults 26–64 Elderly 65+ 5.2.4.1.3 Likely…
GABAA Receptor α1 Subunit (Gabra1) Knockout Mice: Review and New Results
Fig. 4.1. (a) A schematic of the 5′ end of the Gabra1 locus. As described in the text, a yeast-mediated recombination step replaced the genomic region to be deleted with…
The Utility of Genetically Modified Animals in Modeling OCD-Spectrum Disorders
Fig. 7.1. Considered an anxiety spectrum disorder, obsessive-compulsive disorder (OCD) shows clinical heterogeneity and substantial overlap with other psychiatric disorders The Obsessive-compulsive spectrum disorders (OCSD) is a grouping of human…
Mutant and Transgenic Tools in Modeling Schizophrenia
PubMedCrossRef 6. Chen J, Lipska BK, Weinberger DR (2006) Genetic mouse models of schizophrenia: from hypothesis-based to susceptibility gene-based models. Biol Psychiatry 59:1180-1188PubMedCrossRef 7. O’Tuathaigh CMP, Babovic D, O’Meara G…
Environmental Enrichment and Gene–Environment Interactions in Mouse Models of Brain Disorders
CrossRefPubMed 2. van Praag H, Kempermann G, Gage FH (2000) Neural consequences of environmental enrichment. Nat Rev Neurosci 1:191-198CrossRefPubMed 3. Grote HE, Hannan AJ (2007) Regulators of adult neurogenesis in…
Genetic Animal Models of Depression
CrossRefPubMed 2. Levinson DF (2006) The genetics of depression: a review. Biol Psychiatry 60:84-92CrossRefPubMed 3. Zimmermann P, Bruckl T, Lieb R, Nocon A, Ising M, Beesdo K et al (2008)…
Genetic Animal Models of Anxiety
CrossRefPubMed 7. Vieweg WV, Julius DA et al (2006) Posttraumatic stress disorder: clinical features, pathophysiology, and treatment. Am J Med 119(5):383-390CrossRefPubMed 8. Phobia AES (2007) U. S. D. o. H….
Rat Mutants with Lateralized Rotational Behavior for Studying Disturbances in Cerebral Asymmetries and Their Involvement in Brain Disorders
Fig. 3.1. Lateralized circling behavior of ci2/ci2 and ci3/ci3 rats. All data are shown as means ± SEM. (a) illustrates the average number of rotations of 88 ci2/ci2 rats in…
Knockout and Mutant Rats
Fig. 2.1. Social play behavior in periadolescent (aged between 28 and 35 days) rats. SERT−/− rats played significantly less compared to SERT+/+ rats. Social aggression has also been studied in…
