In the MeCP2Bird model (18), male and female mice appeared normal till the third postnatal week, afterward both sexes developed gross abnormalities (with sex-dimorphic time course) consisting of a stiff,…
Fig. 1.1. Wild type (top) and long-fin mutant (bottom) zebrafish. Additionally, a zebrafish model of Huntington’s disease (HD) was generated through a reverse genetics technique, using a morpholino (antisense morpholino-modified…
and Wah Chin Boon2 (1) Mental Health Institute of Victoria, Parkville, VIC, Australia (2) Howard Florey Institute, Parkville, VIC, Australia Abstract Estrogens are C-18 phenolic steroids derived from cholesterol and occur…
Fig. 5.1. Main circuits of the basal ganglia (motor and nonmotor loops). The basal ganglia (bold characters) include: (1) the corpus striatum divided into neostriatum (putamen, caudate nucleus, and nucleus…
, Keiichi Niikura2, Akira Yamashita2, Daigo Ikegami2, Naoko Kuzumaki2, Michiko Narita2 and Tsutomu Suzuki3 (1) Life Science Tokyo Advanced Research Center (L-StaR), 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan (2) Department of Pharmacology, Hoshi University School of Pharmacy…
, George F. Koob1 and Leandro F. Vendruscolo1 (1) Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA 92037, USA Abstract Animal models…
© Springer Science+Business Media New York 2014Carolyn A. Fairbanks and Thomas J. Martin, Ph.D. (eds.)Neurobiological Studies of Addiction in Chronic Pain StatesContemporary Clinical Neuroscience1710.1007/978-1-4939-1856-0_2 2. Opioid Self-Administration in the Presence of Chronic Pain: Analgesia or…
© Springer Science+Business Media New York 2014Carolyn A. Fairbanks and Thomas J. Martin, Ph.D. (eds.)Neurobiological Studies of Addiction in Chronic Pain StatesContemporary Clinical Neuroscience1710.1007/978-1-4939-1856-0_8 8. Opioids in an Evidence-Based World Scott A. Strassels1 (1) Department of Health…
Study Species Pain model Dose of morphine and route of administration Confirmed analgesic effect of morphine Time in chamber during drug pairing Morphine CPP outcome in subjects with chronic pain…
© Springer Science+Business Media New York 2014Carolyn A. Fairbanks and Thomas J. Martin, Ph.D. (eds.)Neurobiological Studies of Addiction in Chronic Pain StatesContemporary Clinical Neuroscience1710.1007/978-1-4939-1856-0_7 7. Prenatal Exposure to Opioids Lisa M. Schrott1 (1) Department of Pharmacology, Toxicology…
