Genetic Animal Models of Depression
CrossRefPubMed 2. Levinson DF (2006) The genetics of depression: a review. Biol Psychiatry 60:84-92CrossRefPubMed 3. Zimmermann P, Bruckl T, Lieb R, Nocon A, Ising M, Beesdo K et al (2008)…
Genetic Animal Models of Anxiety
CrossRefPubMed 7. Vieweg WV, Julius DA et al (2006) Posttraumatic stress disorder: clinical features, pathophysiology, and treatment. Am J Med 119(5):383-390CrossRefPubMed 8. Phobia AES (2007) U. S. D. o. H….
Rat Mutants with Lateralized Rotational Behavior for Studying Disturbances in Cerebral Asymmetries and Their Involvement in Brain Disorders
Fig. 3.1. Lateralized circling behavior of ci2/ci2 and ci3/ci3 rats. All data are shown as means ± SEM. (a) illustrates the average number of rotations of 88 ci2/ci2 rats in…
Knockout and Mutant Rats
Fig. 2.1. Social play behavior in periadolescent (aged between 28 and 35 days) rats. SERT−/− rats played significantly less compared to SERT+/+ rats. Social aggression has also been studied in…
Investigating Rett Syndrome Through Genetic Mouse Models: Presymptomatic, Clearly Symptomatic Phases, and Innovative Therapeutic Approaches
In the MeCP2Bird model (18), male and female mice appeared normal till the third postnatal week, afterward both sexes developed gross abnormalities (with sex-dimorphic time course) consisting of a stiff,…
Mutant and Transgenic Zebrafish in Modeling Neurobehavioral Disorders
Fig. 1.1. Wild type (top) and long-fin mutant (bottom) zebrafish. Additionally, a zebrafish model of Huntington’s disease (HD) was generated through a reverse genetics technique, using a morpholino (antisense morpholino-modified…
Estrogen-Deficient Mouse Models in the Study of Brain Injury and Disease
and Wah Chin Boon2 (1) Mental Health Institute of Victoria, Parkville, VIC, Australia (2) Howard Florey Institute, Parkville, VIC, Australia Abstract Estrogens are C-18 phenolic steroids derived from cholesterol and occur…
Basal Ganglia Disorders in Genetic Models and Experimentally Induced Lesions
Fig. 5.1. Main circuits of the basal ganglia (motor and nonmotor loops). The basal ganglia (bold characters) include: (1) the corpus striatum divided into neostriatum (putamen, caudate nucleus, and nucleus…
Chronic Pain Stimuli Downregulate Mesolimbic Dopaminergic Transmission: Possible Mechanism of the Suppression of Opioid Reward
, Keiichi Niikura2, Akira Yamashita2, Daigo Ikegami2, Naoko Kuzumaki2, Michiko Narita2 and Tsutomu Suzuki3 (1) Life Science Tokyo Advanced Research Center (L-StaR), 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan (2) Department of Pharmacology, Hoshi University School of Pharmacy…
Drug Addiction and Chronic Pain: A Review of Animal Models
, George F. Koob1 and Leandro F. Vendruscolo1 (1) Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA 92037, USA Abstract Animal models…
