Fig. 12.1 Quadriceps muscle biopsy from the present patient. HE stain shows increased fiber size variation with a few atrophic and hypertrophic fibers, and numerous internal nuclei. Many fibers contain…
Fig. 17.1 Myofibrillar myopathy. (a) H&E stain. (b) Gomori trichrome stain. (c) NADH-TR stain. (d) ATPase stain at pH 9.4. (e) Desmin immunostain. (f) Granulofilamentous material on electron microscopy Final Diagnosis…
Fig. 42.1 PGP9.5 immunostaining shows normal cutaneous innervation with many intraepidermal nerve fibers (arrows) present at the unaffected right proximal thigh (a), but no intraepidermal nerve fibers are seen at…
Fig. 40.1 PGP9.5 immunostaining of skin biopsy sections shows reduced intraepidermal nerve fiber densities at the left distal leg (a), distal thigh (b) and proximal thigh (c) with no distal-to-proximal…
Fig. 13.1 Glycogen storage myopathy. (a), H&E stain shows many fibers containing subsarcolemmal vacuoles or blebs (arrows). (b), EM shows striking subsarcolemmal glycogen accumulations (arrows) Additional Investigation After the Muscle…
Fig. 38.1 (a), Intravascular lymphoma in an endomyseal blood vessel (arrow). Tumor cells distend the vascular lumen, have large nuclei and prominent nucleoli; these features are typical of a large…
Fig. 37.1 H&E stain (a) shows nerve infiltration by abundant tumor cells (arrows). The tumor cells have large nuclei and prominent nucleoli; these features are typical of a large cell…
Fig. 36.1 Nerve biopsy , leprous neuropathy. (a), An H&E-stained paraffin section of the superficial radial nerve biopsy, demonstrating a well-formed granuloma (arrow). (b), Fite stained longitudinally oriented paraffin section,…
Fig. 35.1 Hematoxylin and eosin stain (HE) of the sural nerve biopsy section shows chronic mononuclear inflammatory cells infiltrating perineurium and surrounding epineurial and endoneurial blood vessels. There is irregular…
Fig. 34.1 Sural nerve biopsy. Plastic toluidine blue stained semi-thin sections at a lower magnification (a) and a higher magnification (b) show a minimally reduced density of myelinated fibers with…
