Fig. 1 Diffusion-based delivery results in a limited area of distribution and reflux along the needle track. Increased flow rate with CED results in a pressurized extracellular bulk flow that…
Fig. 1 Time-course analysis of early GL26-Cit glioma growth in the striatum in mice. To visualize perivascular glioma growth GL26-Cit cells were implanted in RA/EGxdelCre mice that express GFP in…
Fig. 1 rAAV2/5 efficiently transduces neurons and produces equal protein expression in the young and aged rat hippocampus (HP). (a–d) Young adult (a and c, 6 months, n = 3) and old…
Model Construct Validity? Reproducible? Progressive nigrostriatal degeneration? Parkinsonian pathology? Parkinsonian symptoms? References Construct validity for idiopathic PD Within group Across groups Striatal DA terminal dysfunction/loss (over weeks) Terminal loss precedes…
Gene knockout Transgenic mice Viral system In vivo electroporation Toxicity No No Potential No Immunogenicity No No Potential No Time specificity No No Yes Yes Site specificity No No…
Fig. 1 Ex vivo delivery of growth factor s targeting skeletal muscles for ALS . A GFP-expressing hMSC line was genetically modified by lentiviral infection to stably release growth factors…
Fig. 1 Infusion system setup: This schematic representation demonstrates all of the components in the infusion system. Starting with a 5 mL syringe (1) mounted onto an infusion pump (2),…
Fig. 1 Photograph of the celiac ganglia under a dissecting microscope. The celiac ganglia (circled) can be located by using the aorta, celiac artery, and superior mesenteric artery as landmarks…
Fig. 1 Setup for free-hand intracerebroventricular injections. (a) Brace arms against the ice bucket for support and stability. Comfortably hold the syringe in one hand with the thumb positioned above…
Fig. 1 Entry site preference of pseudotyped lentiviral vectors into neuronal cells. Lentiviral vector pseudotyped with VSV-G mainly enters the cell body areas of neurons, whereas the HiRet/NeuRet vectors with…
