19 Sleep Disturbances Hypersomnia and Sleep Attacks General Recommendations Sleep attacks may occur, although rarely, with several psychotropic agents, most notably certain dopamine agonists (e.g., pramipexole, ropinirole) and MAOIs. Antihistaminergic…
18 Ophthalmological System Cataracts General Recommendations Product labeling for quetiapine includes mention of the potential for development of cataracts, as well as a recommendation for periodic slit-lamp examinations, although no…
16 Musculoskeletal System Joint Pain General Recommendations Joint pains are rarely iatrogenic. Clinicians should determine whether such complaints may reflect other medical causes. Persistent idiosyncratic joint pains may warrant discontinuation…
14 Hematological System Myelosuppression: Agranulocytosis and Thrombocytopenia General Recommendations Clinicians should recognize the risk for agranulocytosis in patients taking carbamazepine or clozapine, and more infrequently in those taking other SGAs or…
11 Endocrinopathies Bone Demineralization and Osteoporosis General Recommendations There is a small increased potential risk for osteoporosis during treatment with carbamazepine or SSRIs. Older adults or other patients who have…
12 Gastrointestinal System Diarrhea, Hypermotility, and Constipation General Recommendations Loose stools may occur during initiation of treatment with serotonergic antidepressants or as part of discontinuation syndromes upon abrupt cessation of…
10 Electrolyte Abnormalities Hyponatremia and SIADH General Recommendations Hyponatremia, with or without syndrome of inappropriate antidiuretic hormone secretion (SIADH), is a relatively rare complication of treatment with virtually all antidepressants,…
8 Dermatological System Alopecia General Recommendations Mineral supplements (e.g., zinc and selenium), oral biotin, or topical minoxidil may be worth attempting for the treatment of alopecia, but scalp hair loss…
9 Ear, Nose, and Throat Bruxism General Recommendations Benzodiazepines such as clonazepam probably offer the most reliable and immediate relief for iatrogenic bruxism. Other potential pharmacological remedies may include buspirone,…
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