The Pathophysiology of Tics
The underlying pathophysiology of tics in Tourette syndrome is a topic of major scientific interest. To date, there is an absence of consensus among researchers regarding the precise anatomic location…
Functional Neuroanatomy of Tics
Tourette syndrome is defined by motor and vocal tics, yet our understanding of the pathophysiology of tics remains limited. Functional MRI (fMRI) can localize brain function related to the clinical…
Genetics of Tourette Syndrome
This review explores the genetic basis of Tourette syndrome (TS), a complex neuropsychiatric disorder characterized by motor and vocal tics. Family, twin, and molecular genetic studies provide strong evidence for…
Genomics of Suicidal Behaviors
Substantial evidence supports the role of genetic factors in suicide behaviors (SBs). The most recent and powered genome-wide association studies identified significant loci for suicide, suicide attempts, and suicide ideation….
An Update on the Psychiatric Genomics of Posttraumatic Stress Disorder (PTSD)
Posttraumatic Stress Disorder (PTSD) is a prevalent psychiatric condition characterized by intrusive thoughts, hyperarousal, avoidance, and negative cognitive alterations following traumatic events. While a significant portion of individuals experience trauma,…
Genomics of Anxiety Disorders
Anxiety disorders are the most prevalent psychiatric conditions in the general population. Despite the early observation of family aggregation of anxiety disorders with a heritability of 30% to 50%, their…
Genomics of Attention Deficit Hyperactivity Disorder
This report provides an update on current knowledge and applications of genomic research in attention deficit hyperactivity disorder (ADHD). The history, principles, and underlying assumptions for genetic studies on psychiatric…
Mainstreaming Diagnostic Genetic Testing and Precision Medicine for Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a neurodevelopmental psychiatric condition that shares significant clinical and genetic overlap with intellectualdisability (ID) and other neurodevelopmental disorders. Genetic testingin ASD lags far behind that…
Genomics of Bipolar Disorder
Bipolar disorder (BD) affects approximately 2% of the global population, characterized by alternating episodes of mania or hypomania, and depression. It comprises two main types: bipolar I disorder, marked by…
Recent Advances in Schizophrenia Genomics and Emerging Clinical Implications
The conceptualization of schizophrenia has evolved from Emil Kraepelin’s identification of “dementia praecox” as a distinct illness characterized by cognitive and functional deficits to the modern understanding of its complex…
