Introduction With a median survival of 12 to 14 months, the prognosis of patients with glioblastoma multiforme (GBM) remains poor. Treatment is therefore not only designed to prolong survival but also…
Introduction Accounting for 52% of all primary brain tumors, glioblastoma is the most common and most aggressive. Glioblastomas account for 20% of all intracranial tumors. Disparities in risk factors, incidence,…
Introduction The traditional principle in neuro-oncology is to study the tumor first, with little consideration regarding the host; that is, the brain. Nevertheless, to define the optimal therapeutic management for…
Background Despite trimodal therapy consisting of maximal safe resection and adjuvant partial radiotherapy with concurrent and subsequent temozolomide, glioblastoma (GBM) has a dismal prognosis, with a median survival of 14.6 months…
Historical context and biological basis Early detection of solid tumors is vital for extending survival and possibly curing patients with cancer. This idea is especially relevant to patients with the most…
Introduction Glioblastoma (GBM) is one of the deadliest forms of cancer, with a median survival of approximately 15 months. Standard of care treatment of GBM includes maximal safe surgical resection, fractionated…
The prognosis following diagnosis of glioblastoma remains poor. Historically, there have been many notable attempts to use local drug delivery to treat glioblastoma, including convection-enhanced delivery (CED), direct tumor injection,…
Introduction Laser interstitial thermal therapy (LITT) is a minimally invasive treatment modality for brain tumors and other central nervous system (CNS) disorders, first introduced by Bown in 1983, which has…
Preoperative surgical evaluation The initial evaluation of a patient with suspected glioblastoma includes history and physical examination, anatomic imaging, and symptom management with seizure medications and corticosteroids. Clinical presentation of…
Introduction The goal of modern surgery for glioblastoma is maximal safe resection. Neurosurgeons are keenly aware of the dramatic negative effects that postoperative neurologic deficits have on survival and quality of life….
