Neupsy Key

Glioblastoma remains a formidable pathologic entity. Without the tools necessary to make a neurologic diagnosis, early medical and surgical clinicians were likely not only puzzled but also appalled by the…

Acknowledgments The authors are grateful to their NYU Langone Medical Center colleagues Matija Snuderl, MD, for contributing illustrated cases of cytogenetics analysis and methylation array; Cyrus Hedvat, MD, PhD, for…

The cellular origin of glioblastoma is complex. Despite decades of research, the understanding of the cellular, molecular, and pathogenetic architecture of this lethal disease is still evolving. Other chapters discuss…

Introduction With an incidence of 3 to 5 per 100,000, glioblastoma fulfills the criteria of a rare cancer. Despite this, glioblastoma is the most common and most aggressive primary brain…

Incidence of glioblastoma Gliomas are the most common type of malignant brain tumor in adults. Of the gliomas, glioblastoma (astrocytoma grade IV) is the most common, and represents approximately 27%…

Acknowledgments This work was supported by National Institutes of Health grants R00HL103792 and R01NS094533 , University of Pennsylvania Neuro-oncology Innovation Award, and McCabe Award (to Y. Fan). Glioma is the…

Acknowledgments The authors would like to acknowledge our colleagues and teachers in neuroradiology at the University of Pennsylvania for their insights on brain tumor imaging, particularly Drs Ronald Wolf, Linda…

Standard-of-care radiation regimens Historical Context of Radiation Therapy and Dose Historically, standard treatment for glioblastoma (GBM) was surgical resection alone. The first randomized trial to show a survival benefit with…

Introduction This chapter reviews the history of angiogenesis and how it was recognized as an essential mechanism for tumor establishment and growth. From the initial recognition of tumor vascularity to…