OVERVIEW Print Section Listen Disorders of neurogenesis, neuronal maturation, and proliferation are responsible for many severe forms of childhood epilepsy. They may arise in discrete cortical areas or involve widespread…
CLINICAL PRESENTATION AND DIAGNOSIS Print Section Listen Acquired epileptic aphasia1 is an epileptic syndrome described in the International Classification of Epilepsies by the eponym Landau–Kleffner syndrome (LKS). Typical LKS2,3 is…
INTRODUCTION Print Section Listen Status epilepticus (SE) is a life-threatening medical emergency that requires prompt recognition and treatment. SE is not a specific disease but rather a manifestation of a…
OVERVIEW Print Section Listen Rasmussen syndrome (RS) or Rasmussen encephalitis (chronic encephalitis and epilepsy) was first described by Rasmussen et al in 1958.1 It is an unusual condition typically developing…
INTRODUCTION Print Section Listen Epilepsies characterized by seizures with a specific mode of precipitation occur in 4%–7% of patients with epilepsy.1 More general factors such as stress, sleep deprivation, and…
CLINICAL PRESENTATION Print Section Listen Sturge–Weber syndrome (SWS) is a nonfamilial neurocutaneous disorder with a potentially progressive course. The syndrome consists of a nevus flammeus (port-wine stain) involving part of…
CLINICAL OVERVIEW Print Section Listen Tuberous sclerosis complex (TSC) is an inherited neurocutaneous disease of cell differentiation and proliferation affecting multiple organs with hamartomas or abnormal neuronal migration. It was…
DEFINITION Print Section Listen The clinical features of the Lennox–Gastaut syndrome (LGS) have been recognized for more than 200 years. The current definition of LGS by the International League Against…
OVERVIEW Print Section Listen In 1841, Dr. William J. West penned a letter to Lancet in which he described an unusual condition in his 4-month-old son, James, that was characterized…
INTRODUCTION Print Section Listen Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a familial focal epilepsy syndrome characterized by frontal lobe seizures occurring predominantly during light sleep. Although not a…
