Abstract Neuromodulation elicited by electrical stimulation of peripheral or spinal nerves is a US Food and Drug Administration–approved therapy for treating several disorders of the pelvic viscera. Although the detailed…
Abstract Burst stimulation was developed based on a very simple principle that mimicking naturally occurring firing patterns might be beneficial for neuromodulation. Its main benefit lies in the capacity of…
Abstract Spinal cord stimulation (SCS) has been used in managing chronic pain conditions that are refractory to current pharmacotherapies. However, conventional SCS has often been associated with suboptimal efficacy and…
Abstract Surgeons, neurologists, researchers, and patients have lacked the technology-based tools to facilitate sharing the tremendously valuable data about patients’ treatment and research in regard to what is working and…
Abstract The safe delivery of electrical currents for the stimulation of neural tissue requires careful consideration of stimulus intensities to avoid tissue and electrode damage. This chapter discusses charge density…
Abstract Advances in magnetic resonance imaging (MRI) are revolutionizing our understanding of brain structure and function. The integration of this technology in patients with neuromodulation devices raises some compatibility and…
Abstract Deep brain stimulation (DBS) is an established clinical therapy for a wide range of neurological disorders and constantly under investigation for increasing indications. Yet even after decades of clinical…
Abstract This chapter covers the fundamentals of localized conduction block of peripheral nerves using kilohertz frequency alternating currents (KHFAC). Experimentally, KHFAC nerve block has been proven to be rapid, reversible,…
Abstract The stimulation waveform describes the applied current, i(t), or voltage, v(t), as a function of time. The characteristics of the stimulation waveform contribute to the effectiveness, efficiency, and risks…
Abstract The immediate and dramatic improvements seen seconds after deep brain stimulation (DBS) in a patient with essential tremor or Parkinson disease, combined with the rapid return of symptoms following…
