Ethosuximide
Ethosuximide Tracy A. Glauser Diego A. Morita HISTORICAL BACKGROUND The development of ethosuximide was a response to the need in the 1950s to develop a more effective, safer, and better…
Phenobarbital and Primidone
Phenobarbital and Primidone Blaise F. D. Bourgeois HISTORICAL BACKGROUND Although its use has been decreasing, phenobarbital is still a major antiepileptic drug (AED). Phenobarbital (PB) has been prescribed for the…
Phenytoin and Fosphenytoin
Phenytoin and Fosphenytoin Diego A. Morita Tracy A. Glauser HISTORICAL BACKGROUND Phenytoin From the second half of the 19th century until 1938, the antiepileptic effect of commonly used medications (sodium…
Carbamazepine and Oxcarbazepine
Carbamazepine and Oxcarbazepine Carlos A. M. Guerreiro Marilisa M. Guerreiro Carbamazepine (CBZ) is one of the most often prescribed drugs worldwide for the treatment of neurologic disorders. It has been…
Pharmacogenetics of Antiepileptic Medications
Pharmacogenetics of Antiepileptic Medications Tracy A. Glauser Diego A. Morita Marked interindividual variation in efficacy and adverse effects, a characteristic of antiepileptic drug (AED) therapy, represents the result of a…
Monitoring for Adverse Effects of Antiepileptic Drugs
Monitoring for Adverse Effects of Antiepileptic Drugs L. James Willmore Andrew Pickens IV John M. Pellock Treatment of patients with epilepsy aims for complete seizure control without intolerable drug side…
Treatment of Epilepsy in the Setting of Renal and Liver Disease
Treatment of Epilepsy in the Setting of Renal and Liver Disease Jane G. Boggs Elizabeth Waterhouse Robert J. DeLorenzo Management of seizures in the presence of renal and liver disease…
Treatment of Epilepsy During Pregnancy
Treatment of Epilepsy During Pregnancy Nancy Foldvary-Schaefer Epilepsy affects nearly 1% of the population, including almost 1 million women of childbearing potential (1). The management of epilepsy during pregnancy can…
Hormones, Catamenial Epilepsy, and Reproductive and Bone Health in Epilepsy
Hormones, Catamenial Epilepsy, and Reproductive and Bone Health in Epilepsy Martha J. Morrell Steroid hormones alter the excitability of neurons of the cerebral cortex and thereby alter the seizure threshold….
