Initiation and Discontinuation of Antiepileptic Drugs Varda Gross Tsur Christine O’Dell Shlomo Shinnar Supported in part by grant 1 R01 NS26151 (S. Shinnar) from the National Institute of Neurological Disorders…
Pharmacokinetics of Antiepileptic Drugs in Infants and Children Gail D. Anderson Jong M. Rho Over the past 20 years, the greater susceptibility to seizures of the immature brain, compared with…
Pharmacokinetics and Pharmacodynamics of Antiepileptic Drugs Blaise F. D. Bourgeois The principles of pharmacokinetics and pharmacodynamics are heavily rooted in mathematics and may, at first, appear far removed from clinical…
Antiepileptic Drug Development and Experimental Models Jacqueline A. French In 1962, the Kefauver-Harris amendments to the federal Food, Drug, and Cosmetic Act ushered in the modern age of drug testing…
Other Nonepileptic Paroxysmal Disorders John M. Pellock A number of conditions cause intermittent and recurring symptoms that suggest epilepsy. Although seizures must be considered in the differential diagnosis, the clinical…
Status Epilepticus James J. Riviello Jr. Status epilepticus (SE) is a life-threatening medical emergency that requires prompt recognition and immediate treatment. SE is not a disease in itself but rather…
Psychogenic Nonepileptic Seizures Selim R. Benbadis OVERVIEW Psychogenic nonepileptic seizures (PNES) are routinely seen at epilepsy centers, where they represent 15% to 30% of patients referred for refractory seizures (1,2)….
Epilepsy in Patients with Multiple Handicaps John M. Pellock Disabilities associated with the varying etiologies of epilepsy or with the disease itself often lead to multiple handicaps that complicate the…
Epilepsy in the Elderly Ilo E. Leppik Angela K. Birnbaum The elderly (persons 65 years of age and older) are the most rapidly growing segment of the population, and onset…
Seizures Associated with Nonneurologic Medical Conditions Stephan Eisenschenk Robin L. Gilmore Seizures frequently arise during the course of medical illnesses that do not primarily affect the central nervous system (CNS)….
