Presurgical Evaluation: General Principles and Methods Gary W. Mathern Michael R. Sperling Introduction Epilepsy surgery is considered when seizures are incompletely controlled by medication and it is apparent that further…
Surgically Remediable Syndromes Jerome Engel Jr. Gregory D. Cascino W. Donald Shields Introduction The safety and efficacy of surgical treatment for epilepsy have improved greatly in recent years as a…
Indications and Criteria for Surgical Intervention Michael S. Duchowny A. Simon Harvey Michael R. Sperling Peter D. Williamson Introduction The estimated lifetime cumulative incidence and prevalence of epilepsy are 3%…
Overview: Surgical Therapy Jerome Engel Jr. Heinz Gregor Wieser Dennis D. Spencer Introduction Surgical treatment for epilepsy has a long and distinguished history.11,15,33 Trephination was practiced since prehistoric times in…
Immunoglobulin and Immunomodulatory Therapy Flavio Villani Christian G. Bien Giuliano G. Avanzini Introduction The use of immunoglobulin in intractable epilepsy is one of its oldest applications in medicine, starting from…
Investigational Drugs: Brivaracetam, Carisbamate, Eslicarbazepine Fluorofelbamate, Gamaxolone, Isovaleramide, Lacosamide (Harkoseride; SPM927), Losigamine, Retigabine, Safinamide, Seletracetam, Stiripentol, Talampanel, and Valrocemide H. Steve White Emilio Perucca Michael D. Privitera Introduction During the…
Trimethadione, Paraldehyde, Phenacemide, Bromides, Sulthiame, Acetazolamide, and Methsuximide Thomas R. Browne Barbara W. LeDuc Maria D. Kosta-Rokosz Edward B. Bromfield R. Eugene Ramsay John De Toledo Introduction Trimethadione, paraldehyde, phenacemide,…
Zonisamide Masakazu Seino Ilo E. Leppik Introduction After a long hiatus in the development of novel drugs for treating epilepsy, the early 1990s saw several new antiepileptic drugs (AEDs) developed…
Vigabatrin Elinor Ben-Menachem Olivier Dulac Catherine Chiron Introduction Vigabatrin is a novel antiepileptic drug (AED). It differs from most other agents in that it was designed to have a specific…
