Retrograde Maculopathy
Fig. 10.1 Typical example of a microcystic macular edema (MME) in a patient with a compressive optic neuropathy. Thickness maps of ganglion cell layer (GCL) and inner nuclear layer (INL)…
NEUROLOGY
MS-Associated Optic Neuritis (MSON)
Disease-free controls All MS MS, no history of MSON MS, history of MSON High-contrast visual acuity (VA), ETDRS, number of letters correct 59 ± 6 (n = 52 eyes) 53 ± 10 (n = 559 eyes) 55 ± 7…
Progressive Multiple Sclerosis (SP and PP MS)
Fig. 9.1 Progressive multiple sclerosis nomenclature. Progressive MS nomenclature according to the current criteria [2] Prior to the 2013 MS disease course revision, the phenotype of a patient with primary…
Role of the OCT Reading Center
Fig. 13.1 Flowchart showing the three major phases of a study and the involvement of the RC in each of these phases During the execution phase, the RC supports several…
Drug Trials in Neuroprotection
Trial (phase) Goal Drug Indication Primary outcome Secondary outcomes Alpha error Power Effect size Sample per arm Status Ref/NCT ACTION (RCT Phase II) Primary neuroprotection I: Amiloride C: Placebo iAON…
OCT Findings in Neuromyelitis Optica Spectrum Disorders
Fig. 6.1 Peripapillary and macular OCT scan from a healthy control (HC; female 30 years old), a multiple sclerosis associated optic neuritis eye (MSON eye; female 32 years old), and…
Monitoring Treatment in Multiple Sclerosis
Fig. 11.1 This is a spectral domain OCT analysis of peripapillary retinal nerve fiber layer (RNFL) thickness in a multiple sclerosis patient with prior left MSON. The RNFL thickness in…
Introduction: Clinical Application of OCT in Multiple Sclerosis
© Springer International Publishing Switzerland 2016Axel Petzold (ed.)Optical Coherence Tomography in Multiple Sclerosis10.1007/978-3-319-20970-8_1 1. Introduction: Clinical Application of OCT in Multiple Sclerosis Sven Schippling1 (1) Neuroimmunology and Multiple Sclerosis Research Section, Department of Neurology, University…
OCT and Early MS: Clinically Isolated Syndromes (CIS)
© Springer International Publishing Switzerland 2016Axel Petzold (ed.)Optical Coherence Tomography in Multiple Sclerosis10.1007/978-3-319-20970-8_7 7. OCT and Early MS: Clinically Isolated Syndromes (CIS) Fiona Costello1 (1) Departments of Clinical Neurosciences and Surgery (Ophthalmology), University of Calgary,…
Anatomy of the Retina and the Optic Nerve
Fig. 2.1 Retinal layers as they appear on spectral domain optical coherence tomography (Reprinted with permission from Staurenghi et al. [16]) Layer 1: Retinal Pigment Epithelium Histologically, the retinal pigment…
