2. Impaired single-word comprehensionAt least three of the following other diagnostic features must be present:1. Impaired object knowledge, particularly for low-frequency or low-familiarity items2. Surface dyslexia or dysgraphia3. Spared repetition4….
Figure 23.1 McKee’s four stages of CTE tau pathology and associated clinical features. The left column depicts 50 μm coronal tissue sections with CP-13 immunostain which labels phosphorylated tau with…
Figure 21.1 Typical brain MRI in a patient with sJCD. FLAIR (top row), DWI (middle row), and ADC map (bottom row) sequences show the typical T2-weighted hyperintensities with corresponding restricted…
Figure 15.1 Algorithm for the diagnosis of mild cognitive impairment. To illustrate diagnosis according to Figure 15.1: an initial clinical and cognitive evaluation may show that the patient has experienced…
Figure 18.1 Lewy-related pathology (LRP). Lewy body inclusion (arrow) in a pigmented neuron of the substantia nigra (A, hematoxylin and eosin). Immunohistochemical staining of Lewy body inclusions (arrow heads) and…
Figure 10.1 Atrophy maps in PPA subtypes [7, 11]. Only the left hemisphere is shown. Areas in red and yellow show peak atrophy sites when patient groups of a given…
Urine analysis and cultureChest radiographElectrocardiogramFurther evaluation guided by initial evaluationBrain imaging with magnetic resonance with contrast (preferred) or computed tomographySerum ammoniaErythrocyte sedimentation rateBlood culturesLumbar puncture (if suspicion of meningitis, should…
Figure 25.1 Overlap in neuropathology among dementia and non-dementia cases in the 90+ Study. Corrada et al., Curr Alzheimer Res. 2012 July 1; 9(6): 709–17. (Reproduced with permission [47].) This…
astheniaNausea, vomiting, diarrhea, depression, headache, anxiety, application site reaction All three medications have shown efficacy through randomized, double-blind placebo-controlled trials (RCTs) with varying durations from 3 to 12 months. Compared…
7 [1–14]f4.5 [3–10]gTypical clinical featuresCognitive featureMCI: any subtype, executive dysfunction, visuospatial dysfunction, verbal blocking, misidentification errors, impaired attention, variable memory impairmentMCI-PD, executive dysfunction, visuospatial dysfunction, impaired attentionMCI-SD executive, MCI-SD language…
