Figure 58-1 Sural nerve biopsy demonstrates severe axonal loss with perivascular lymphocytic infiltration (Epon) in the epineurium (left) and CD79a positivity of lymphocytes (right). CONCLUSIONS The exact incidence of extrahepatic…
A key pathologic feature characteristic of ALS neurons is the presence of intracytoplasmic deposits of ubiquinated immunoreactive inclusions, recently shown to be the protein TDP-43, a nuclear factor about which…
Figure 55-1 Serial longitudinal paraffin sections show congophilic deposits surrounding endoneurial microvessels (Congo red stain, upper left) and apple green birefringence under polarized light (upper right). The section in the…
Sensory deficit Sensory deficit Sensory dissociation Common Rare Autonomic dysfunction in early stages Severe with ADL disturbance Mild without ADL disturbance Cardiac involvement Atrioventricular conduction block Cardiomegaly Anticipation of age…
Figure 54-1 The structure of infliximab. (Adapted from Knight DM, Trinh H, Le J, Siegel S, Shealy D, McDonough M, Scallon B, et al. Construction and initial characterization of a…
Figure 52-1 Sural nerve biopsy from a patient with peripheral neuropathy after bariatric surgery demonstrating very active axonal degeneration. Teased fiber preparations (upper left) show almost all fibers are undergoing…
Figure 50-1 Selected microscopic fields from sural biopsy from the patient presented. The upper frame is a paraffin section stained with hematoxylin and eosin that demonstrates a giant cell (arrow)…
Figure 44-1 Cross-section of right sural nerve biopsied at ankle level. Nerve conduction studies of this nerve performed 1 week before biopsy were within normal limits. This methylene blue–stained semithin…
Figure 19-1 Serial transverse paraffin sections. A, Hematoxylin and eosin section demonstrates multiple whorl-like structures corresponding to microfascicles (arrow) replacing the normal architecture of the nerve. Note one preserved nerve…
Figure 26-1 Pes cavus, right toe drop, wasting of intrinsic hand muscles, hyperpigmented scars and joint creases. Figure 26-2 Mucosal pigmentation, best seen at the side of the tongue. Nerve…
