Name Biologically active peptide(s) secreted Incidence Tumor location Malignant % Associated with MEN-1, % Main symptoms/signs ACTHoma ACTH Rare Pancreas >95 Rare Cushing’s syndrome (100 %) CRHoma, Corticotropin-releasing hormone Rare…
12.3.1 Reactive “Functional Hypoglycemia” Reactive “functional hypoglycemia” is a controversial entity, and it is now known that many organic disorders may result both in fasting and/or reactive hypoglycemia. Many patients…
Name SST1 SST2 SST3 SST4 SST5 Ga-DOTATATE >10,000 0.2 ± 0.04 >10,000 300 ± 140 377 ± 18 Ga-DOTATOC >10,000 2.5 ± 0.5 613 ± 140 >1,000 73 ± 21 Ga-DOTANOC >10,000 1.9 ± 0.4 40 ± 5.8 260 ± 74 7.2 ± 1.6 Data from Refs. [15, 16] SST…
19. Sakura A (1988) Paul Langerhans (1847–1888): a centenary tribute. J R Soc Med 81:414–415 20. Heidenhain R (1870) Untersuchungen uber den Bau der Labdrusen. Arch Mikr Anat 6:368CrossRef 21….
© Springer-Verlag Berlin Heidelberg 2015Suayib Yalcin and Kjell Öberg (eds.)Neuroendocrine Tumours10.1007/978-3-662-45215-8_14 14. VIPoma and PPoma Christian Rolfo1, Giuseppe Bronte2, Leonor Leider3, Patrick Pauwels4, Konstantinos Papadimitriou1, Antonio Russo2 and Marc Peeters1 (1) Oncology Department and Multidisciplinary Oncology Center of Antwerp (MOCA), Antwerp University…
Mitosis index Ki-67 index (%) ENETS/WHO definition <2 <3 NET Grade I 2–20 3–20 NET Grade II >20 >20 NEC (small cell or large cell) Grade III Mixed adenoneuroendocrine carcinoma…
Fig. 4.1 In NETs, the study of inherited syndromes allowed the identification of the common deregulation of genes involved in the mTOR pathway in these tumors. As a master regulator…
Name Neuroendocrine tumor (NET) (frequency) MEN-1 syndrome (MEN-1) (MIM 131100) Pituitary adenoma (5–65 %) (Wermer’s syndrome) Pancreatic NET (80–100 %) Thymic NET (mostly ♂), (<10 %) Lung NET (20–25 %)…
Foregut carcinoids Midgut carcinoids Hindgut carcinoids Thymus Jejunum Transverse colon Bronchus Ileum Descending colon Stomach Ascending colon Sigmoid colon Duodenum Caecum Rectum Appendix Genitourinary tract The ENETS classification 2006/2007, the…
Fig. 10.1 Sustained increase of oxygenated hemoglobin (oxyHb) signals during treadmill walking in a patients with cerebellar ataxia. While oxyHb signals in the prefrontal cortex gradually decreased during treadmill walking…
