Symptom Dementia MND ExPy Accumulated protein α-Synuclein DLB PD, MSA Aβ AD Tau AD FTD PSP, CBD TDP-43 FTD ALS FUS FTD ALS Note: Correlations among the typical neurodegenerative…
Insult Effect Axonal degeneration Neuronal apoptosis References 6OHDA Some axons preserved for ~11 days + − Sajadi et al. (2004) MPTP Enhances survival, prevents nigrostriatal axon degeneration, and attenuates neurotransmitter loss…
Fig. 11.1 Conjunction of small networks centered upon patients 11.4.5 Social Program or System For continuing home-based care, consideration of the economic costs as well as the human costs associated…
Fig. 9.1 Abnormal protein misfolding and aggregation as the common molecular pathogenesis of neurodegenerative diseases. Most of the genetic mutations responsible for the inherited neurodegenerative diseases commonly render the mutant…
Fig. 5.1 Clinical systems neuroscience consists of multi-layered sub-disciplines with different spatial scales: molecular neuroscience (nanometer), cellular neuroscience (micrometer), systems neuroscience and cognitive/behavioral neuroscience (millimeter to centimeter). Advances in non-invasive…
© Springer Japan 2015Keiji Wada (ed.)Neurodegenerative Disorders as Systemic Diseases10.1007/978-4-431-54541-5_13 13. Social Implementation of Neurodegenerative Disease Research and Neuroethics Tamami Fukushi1 (1) Platform for Regenerative Medicine, Foundation for Biomedical Research and Innovation (FBRI), Kobe, Japan…
Fig. 7.1 Two concepts of intermediate phenotype approach. Susceptibility genes for neuropsychiatric disorders do not directly encode for the clinical syndrome/behaviors. The abnormal behaviors observed in neuropsychiatric disorders are produced…
Fig. 6.1 The genetic and environmental factors that contribute to the occurrence of neurodegenerative diseases. (Left) Disease defined by a mutation in a single gene (as observed in monogenic Mendelian…
Fig. 2.1 A schematic diagram of two neural routes that mediate peripheral organ–brain interactions: (A) The afferent vagus–nucleus tract solitarii (NTS) axis. Information on the visceral organs is transmitted to…
Fig. 3.1 Immune response in SCI (immune system–brain interaction): (A) following initial injury, neutrophils and macrophages (monocytes) invade the lesion by activating resident microglia; (B) then, T and B cells…
