INTRODUCTION Print Section Listen In this chapter, we describe the pathophysiology, clinical presentation, laboratory findings, and treatment of the nondystrophic myotonias and periodic paralyses (Table 31-1). There are several inherited…
INTRODUCTION Print Section Listen Limb pain, diminished sensation (numbness), altered sensory perception (paresthesias and dysesthesias) and impaired function due to weakness are exceedingly common complaints in the practice of medicine….
INTRODUCTION Print Section Listen The inherited metabolic myopathies are traditionally classified by their underlying biochemical abnormalities as disorders of (1) carbohydrate, (2) lipid, and (3) adenine nucleotide metabolism. A fourth…
INTRODUCTION Print Section Listen Hereditary neuropathies may account for as many as 50% of previously undiagnosed peripheral neuropathies referred to large neuromuscular centers. Charcot–Marie–Tooth (CMT) disease is the most common…
INTRODUCTION Print Section Listen This chapter describes the disorders of neuromuscular transmission (DNMT) other than myasthenia gravis (MG) (Table 26-1). The neuromuscular junction (NMJ) is a physiologically complex structure. Its…
INTRODUCTION Print Section Listen Acquired, autoimmune myasthenia gravis (MG), the most common noniatrogenic disorder of neuromuscular transmission (DNMT), remains the favorite child of many neuromuscular clinicians. Arguably, it provides more…
INTRODUCTION Print Section Listen In Chapter 11, we reviewed Charcot–Marie–Tooth syndrome and related hereditary neuropathies. Here we discuss some of the more rare types of hereditary neuropathies (Table 12-1). Familial…
INTRODUCTION Print Section Listen Myopathies can occur in the setting of a variety of systemic diseases. Previous chapters have discussed inflammatory myopathies that can occur in the setting of connective…
INTRODUCTION Print Section Listen Neuropathies are associated with a number of systemic disorders (Table 16-1). Neuropathies related to vasculitis, infection, endocrinopathies, cancer, and medications are discussed in other chapters. The…
INTRODUCTION Print Section Listen Patients with malignancy can develop peripheral neuropathies as the result of (1) a direct effect of the cancer by invasion or compression of the nerves, (2)…
