Other and Newer Antidepressants
Other and Newer Antidepressants Agomelatine Agomelatine is a new antidepressant with MT1 and MT2 melatonergic agonist and 5-HT2C antagonist actions which has been shown to be effective in severe depression…
Other Drugs Used in Psychiatry
Other Drugs Used in Psychiatry Benzodiazepines During the 1960s benzodiazepines were routinely used as hypnotics (e.g. nitrazepam and temazepam), and anxiolytics (e.g. diazepam and chlordiazepoxide). The Committee on Safety of…
Treatment-Resistant Depression
Treatment-Resistant Depression Treatment-resistant depression Although there is no generally accepted definition of treatment-resistant depression, NICE defines treatment-resistant depression as that which fails to respond to two or more antidepressants given…
Selective Serotonin Re-Uptake Inhibitors
Selective Serotonin Re-Uptake Inhibitors The use of SSRIs As implied by their name, the selective serotonin re-uptake inhibitors, commonly abbreviated to SSRIs, selectively inhibit the re-uptake of the neurotransmitter serotonin…
Tricyclic and Related Antidepressant Drugs
Tricyclic and Related Antidepressant Drugs The use of tricyclic antidepressants Ever since Kuhn (1958) discovered the antidepressive actions of the archetypal tricyclic antidepressant imipramine, tricyclic antidepressants and related drugs have…
Monoamine-Oxidase Inhibitors
Monoamine-Oxidase Inhibitors The use of MAOIs The enzyme monoamine oxidase (MAO), found mainly in the external mitochondrial membrane, acts on central nervous system neurotransmitters such as noradrenaline, serotonin, and dopamine….
Antimanic Drugs
Antimanic Drugs The use of antimanic drugs The antimanic drugs considered in this chapter are lithium salts, carbamazepine, and semisodium valproate (containing valproic acid). Lithium carbonate and lithium citrate are…
Antipsychotic Depot Injections
Antipsychotic Depot Injections Administration Long-acting antipsychotic depot injections may be administered to adults by deep intramuscular injection. They should not be given to children. Advantages and disadvantages This form of…
Treatment-Resistant Schizophrenia
Treatment-Resistant Schizophrenia Treatment-resistant schizophrenia In 2009, NICE published the following guidance for the treatment of patients suffering from schizophrenia who have not responded adequately to treatment. Related posts: Drug Treatment…
Non-Depot Antipsychotic Drugs
Non-Depot Antipsychotic Drugs Use of antipsychotic drugs Antipsychotic drugs (also known as ‘neuroleptics’) have a wide variety of uses in psychiatric practice. The main uses of antipsychotic drugs include the…
