MRI-Guided Delivery of Viral Vectors

Sep 24, 2016 by in NEUROLOGY Comments Off on MRI-Guided Delivery of Viral Vectors

Fig. 1 Infusion system setup: This schematic representation demonstrates all of the components in the infusion system. Starting with a 5 mL syringe (1) mounted onto an infusion pump (2),…

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Altering Entry Site Preference of Lentiviral Vectors into Neuronal Cells by Pseudotyping with Envelope Glycoproteins

Sep 24, 2016 by in NEUROLOGY Comments Off on Altering Entry Site Preference of Lentiviral Vectors into Neuronal Cells by Pseudotyping with Envelope Glycoproteins

Fig. 1 Entry site preference of pseudotyped lentiviral vectors into neuronal cells. Lentiviral vector pseudotyped with VSV-G mainly enters the cell body areas of neurons, whereas the HiRet/NeuRet vectors with…

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Altering Tropism of rAAV by Directed Evolution

Sep 24, 2016 by in NEUROLOGY Comments Off on Altering Tropism of rAAV by Directed Evolution

Fig. 1 Library enrichment for target-specific variants. The DNA encoding the initial capsid library (top left) is cloned into the vector and enters the cycle through which target-specific variants are…

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AAV-Mediated Gene Transfer to Dorsal Root Ganglion

Sep 24, 2016 by in NEUROLOGY Comments Off on AAV-Mediated Gene Transfer to Dorsal Root Ganglion

Fig. 1 Intraganglionic injection. Paravertebral surgical exposure for intraganglionic injection, illustrating the operative field (left panel), reference diagram (middle panel), and cleaned vertebral bones (right panel). (a) Initial dissection of…

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AAV2-Neurturin for Parkinson’s Disease: What Lessons Have We Learned?

Sep 24, 2016 by in NEUROLOGY Comments Off on AAV2-Neurturin for Parkinson’s Disease: What Lessons Have We Learned?

© Springer Science+Business Media New York 2016Fredric P. Manfredsson (ed.)Gene Therapy for Neurological DisordersMethods in Molecular Biology138210.1007/978-1-4939-3271-9_32 32. AAV2-Neurturin for Parkinson’s Disease: What Lessons Have We Learned? Jeffrey H. Kordower1   (1) Department of Neurological Sciences, Rush…

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Gene Therapy for the Treatment of Neurological Disorders: Metabolic Disorders

Sep 24, 2016 by in NEUROLOGY Comments Off on Gene Therapy for the Treatment of Neurological Disorders: Metabolic Disorders

© Springer Science+Business Media New York 2016Fredric P. Manfredsson (ed.)Gene Therapy for Neurological DisordersMethods in Molecular Biology138210.1007/978-1-4939-3271-9_30 30. Gene Therapy for the Treatment of Neurological Disorders: Metabolic Disorders Dominic J. Gessler1 and Guangping Gao1   (1) University of…

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