Tumor-Specific Approach: Oligodendroglioma (IDH1 Mutated, 1p/19q Deleted)

Oct 17, 2017 by in NEUROLOGY Comments Off on Tumor-Specific Approach: Oligodendroglioma (IDH1 Mutated, 1p/19q Deleted)

© Springer International Publishing AG 2017Jennifer Moliterno Gunel, Joseph M Piepmeier and Joachim M. Baehring (eds.)Malignant Brain Tumors 10.1007/978-3-319-49864-5_17 17. Tumor-Specific Approach: Oligodendroglioma (IDH1 Mutated, 1p/19q Deleted) Charles Marc Leyrer1  , Erin Murphy1   and Manmeet Ahluwalia2   (1) 9500 Euclid Ave./T-28, Cleveland,…

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Infiltrative Glioma

Oct 17, 2017 by in NEUROLOGY Comments Off on Infiltrative Glioma

Fig. 16.1 Schematic overview of a possible clinical decision algorithm outside clinical trials for infiltrative glioma. IDH isocitrate dehydrogenase; ATRX alpha thalassemia mental retardation X-linked; MGMT O6 methylguanine methyltransferase; G–CIMP glioma-CpG…

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Glioma Radiosensitizers: Exciting New Developments and Directions

Oct 17, 2017 by in NEUROLOGY Comments Off on Glioma Radiosensitizers: Exciting New Developments and Directions

© Springer International Publishing AG 2017Jennifer Moliterno Gunel, Joseph M Piepmeier and Joachim M. Baehring (eds.)Malignant Brain Tumors 10.1007/978-3-319-49864-5_15 15. Glioma Radiosensitizers: Exciting New Developments and Directions Christopher D. Corso1   and Ranjit S. Bindra1   (1) Department of Therapeutic Radiology, Yale…

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Mapping the Brain for Primary Brain Tumor Surgery

Oct 17, 2017 by in NEUROLOGY Comments Off on Mapping the Brain for Primary Brain Tumor Surgery

Fig. 5.1 Illustrative case of a 50 years-old frustrated left-handed patient diagnosed with a left frontal glioblastoma revealed by headaches and language disturbances. a Preoperative T1-gadolinium enhanced MRI, showing a large enhancing…

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Novel Delivery Strategies

Oct 17, 2017 by in NEUROLOGY Comments Off on Novel Delivery Strategies

Carrier Treatment Phase Study population # of patients Results Reference Nanoparticles Aminosilane-coated iron oxide particles and alternating magnetic fields I Recurrent grade IV astrocytoma 14 • Minor or no side…

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Antiangiogenic Therapy for Malignant Gliomas

Oct 17, 2017 by in NEUROLOGY Comments Off on Antiangiogenic Therapy for Malignant Gliomas

Trial Phase Disease type Patients (n) Arms Median PFS (mo) PFS-6 (%) Median OS (mo) Reference BRAIN 2 rGBM 167 BEV 4.2 42.6 9.2 [37] BEV + irinotecan 5.6 50.3 8.7 NCI 2 rGBM 48 BEV…

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Targeting Aberrant Signaling Pathways

Oct 17, 2017 by in NEUROLOGY Comments Off on Targeting Aberrant Signaling Pathways

Fig. 9.1 Critical signaling pathways altered in malignant gliomas. Primary sequence alterations and significant copy number changes for the components of the a | RTK/RAS/PI3K, b | p53, and c |…

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Current Standard Treatment Options for Malignant Glioma

Oct 17, 2017 by in NEUROLOGY Comments Off on Current Standard Treatment Options for Malignant Glioma

Fig. 8.1 a Magnetic resonance imaging of brain—glioblastoma magnetic resonance imaging reveals the aggressive nature of glioblastoma with the typical ring enhancement, central necrosis, and significant mass effect. b Magnetic resonance…

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