1 Chapter 1 : Fundamentals of neuropathology: introduction to neuropathology and molecular diagnostics a. Classification of glioblastoma i. Microvascular proliferation and pseudopalisading necrosis are pathologic hallmarks of glioblastoma (GBM) and,…
Introduction Immune-based therapies have revolutionized cancer treatment. These agents enhance the immune system’s ability to seek out and attack tumor cells. One such treatment, CAR T-cells or chimeric antigen receptor…
Brief introduction to immunotherapy Immune-based therapies have emerged as a promising modality in cancer treatment. These therapies use the body’s immune system to fight cancer by harnessing the antitumor properties…
Introduction With significant advances in cancer treatment, both the number of long-term cancer survivors and the complications to which these patients are vulnerable have grown. These complications can involve the…
Introduction Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common side effects of cytotoxic chemotherapy and presents as a distal, symmetric polyneuropathy ( Table 28.1 ). Rates of CIPN…
Introduction Cranial irradiation is used in settings ranging from definitive treatment of primary brain and head and neck cancers to palliation of metastatic disease and prophylaxis, as a single modality…
Introduction Cognitive abilities in glioma patients are influenced by a myriad of factors: the tumor itself, depression and anxiety, fatigue, sleep dysfunction, pre–brain tumor cognitive baseline (e.g., premorbid functioning), pain,…
Introduction Cerebral radiation necrosis is a challenging and potentially devastating complication of cranial irradiation. Based on the temporal relationship to radiation therapy (RT), it can be classified as pseudoprogression (a…
Acknowledgments We thank Dr. Andrew McKeon (Departments of Laboratory Medicine and Pathology and Neurology, Mayo Clinic, Rochester, Minnesota) for providing Case 23.6: Paraneoplastic neurological syndrome. Introduction Malignant cells of both…
Introduction Despite the development of new therapies and related neurological complications, the two main considerations in patients with a history of cancer presenting with a brachial or lumbar plexopathy is…
