6 Neurofibromas and Malignant Peripheral Nerve Sheath Tumors (MPNST) in Neurofibromatosis 1 The growth of multiple neurofibromas is not only the hallmark feature of neurofibromatosis 1 (NF1), but also is…
9 Other Features of Neurofibromatosis 1 In addition to the common manifestations of neurofibromatosis 1 (NF1), a variety of seemingly unrelated manifestations are associated with the disorder. These less common…
2 The Many Faces of Neurofibromatosis The diagnosis of neurofibromatosis is based on clinical criteria established mainly through a detailed medical history and physical examination. Although other varieties of neurofibromatosis…
3 The Pathogenesis of Neurofibromatosis 1 and Neurofibromatosis 2 The neurofibromatoses are genetic disorders. NF1 and NF2 are each caused by a mutation in a known specific gene. The quest…
10 Diagnosis and OverallManagement ofNeurofibromatosis 2 The hallmark feature of neurofibromatosis 2 (NF2) is a slow-growing tumor on the eighth cranial nerve in both ears. This nerve has two branches….
12 Schwannomatosis Schwannomatosis is a newly recognized form of neurofibromatosis that is distinct from neurofibromatosis 1 (NF1) and neurofibromatosis 2 (NF2), in terms of both its primary clinical features and…
11 Management of Particular Neurofibromatosis 2 Features A diagnosis of confirmed or probable neurofibromatosis 2 (NF2) raises a host of new challenges. Optimal management of the disorder depends on several…
15 Research About Neurofibromatosis Although the past decade has yielded many new insights into the genetic and molecular abnormalities that cause neurofibromatosis, many questions remain about how its manifestations develop…
14 Practical and Quality-of-Life Issues This chapter focuses on the major practical and quality-of-life aspects of living with neurofibromatosis (NF). Logistical challenges include coordinating multiple medical visits, navigating the insurance…
13 Psychosocial Impact of Neurofibromatosis Neurofibromatosis (NF) has a psychosocial impact that consists of psychological, social, economic, and quality-of-life issues. Psychosocial issues pervade the life of not only the individual…
